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Table 2 Characteristics of the casecontrol replication study groups

From: Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease

Characteristic COPDGene ECLIPSE NETT/NAS GenKOLS
Cases Controls Cases Controls Cases Controls Cases Controls
Number of participants 499 501 1764 178 373 435 863 808
Age (mean ± SD), years 64.77 ± 8.12 60.20 ± 8.66 63.63 ± 7.10 57.48 ± 9.44 67.47 ± 5.78 69.8 ± 7.49 65.53 ± 10.03 55.62 ± 9.71
Smoking history (mean ± SD), pack-yearsa 54.76 ± 26.69 38.87 ± 21.07 50.29 ± 27.42 32.11 ± 24.84 66.43 ± 30.68 40.66 ± 27.85 31.98 ± 18.46 19.66 ± 13.58
FEV1 (mean ± SD), % predictedb 48.73 ± 18.41 97.98 ± 11.32 47.63 ± 15.62 107.83 ± 13.56 28.12 ± 7.38 99.97 ± 13.20 50.63 ± 17.44 94.91 ± 9.24
Sex (% male) 49.5% 50.1% 67.0% 57.9% 63.8% 100% 60.1% 50.1%
  1. aNumber packs of cigarettes smoked per day × number of years of smoking.
  2. bLung function was measured as forced expiratory volume in 1 second (FEV 1) as a percentage of the predicted value.