Exhaled nitric oxide is related to atopy, but not asthma in adolescents with bronchiolitis in infancy

BMC Pulmonary Medicine

Table 5 Linear regression model explaining fractional exhaled nitric oxide (FeNO) given as ln FeNO at 11 years of age in 105 children hospitalized for bronchiolitis and 89 children in an age matched control group, all children analysed together

	Unadjusted models			Fully adjusted model (N = 190)			Final model (N = 190)
Risk factors	B^*	95% CI	P-value	B^*	95% CI	P-value	B^*	95% CI	P-value
Hospitalization for bronchiolitis	−0.200	−0.408, 0.008	0.059	−0.088	−0.276, 0.101	0.359
Male gender	−0.131	−0.342, 0.080	0.223
Age at follow up (months)	0.009	−0.006, 0.024	0.257
Height (cm)	0.021	0.007, 0.034	0.002	0.025	0.008, 0.042	0.005	0.027	0.015, 0.038	<0.001
Weight (kg)	0.014	0.004, 0.025	0.009	0.001	−0.012, 0.014	0.849
Atopy	0.736	0.539, 0.934	<0.001	0.757	0.562, 0.951	<0.001	0.773	0.583, 0.962	<0.001
Current asthma	0.035	−0.243, 0.313	0.805
Ln DRS	0.053	−0.003, 0.108	0.062	0.056	0.008, 0.105	0.023	0.051	0.004, 0.097	0.034
FEV₁%	0.006	−0.004, 0.016	0.269
FEF_25-75%	0.001	−0.003, 0.006	0.597
Use of inhaled steroids preceding 12 months	0.200	−0.169, 0.568	0.287

No interactions were found between current asthma and atopy, atopy and DRS, atopy and hospitalization for bronchiolitis or DRS and hospitalization for bronchiolitis.
^*Regression coefficient, represents the amount of change of ln NO induced by a change of 1 unit of the explanatory variable.
CI, confidence interval; DRS, dose response slope; FEV₁%, forced expiratory volume in first second as percentage of predicted; FEF_25-75%, forced expiratory flow between 25-75% of the forced vital capacity.
Bold values indicate significance at the 0.05 level.

ISSN: 1471-2466