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Table 5 Experiment 2: Concentrations of prostaglandin E 2 , leukotriene B 4 , thromboxane B 2 and 8-isoprostane measured in lung perfusate samples collected at the end of MV

From: The effects of exogenous surfactant administration on ventilation-induced inflammation in mouse models of lung injury

  Air Acid
Mediator (pg/ml) No treatment bLES No treatment bLES
Prostaglandin E2 14.3 ± 2.0 26.8 ± 3.9 147.4 ± 40.3 221.7 ± 89.2*
Leukotriene B4 14.4 ± 5.2 10.6 ± 5.3 13.1 ± 7.3 41.9 ± 12.3
Thromboxane B2 52.7 ± 10.1 67.8 ± 12.9 109.9 ± 24.8 134.9 ± 43.6
8-Isoprostane 11.3 ± 1.6 19.7 ± 3.0 47.2 ± 8.1* 70.4 ± 12.5*
  1. Data are expressed as mean ± SEM; n = 6 per group. *p < 0.05 versus the respective Air control.