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Table 1 Anthropometric, medication and liver function data of subject groups

From: Inflammatory cytokine response to exercise in alpha-1-antitrypsin deficient COPD patients ‘on’ or ‘off’ augmentation therapy

  AATD + AUGa AATD + AUGb TD PFTnormc non-AATD COPDd Healthye
Lung health classification COPD COPD Normal COPD Normal
Genotype PiZZ PiZZ (PiSZ = 1) PiZZ PiMM PiMM (PiMZ = 1)
Number of subjects (m,f) 6 (3,3) 6 (2,4) 4 (1,3) 7 (4,3) 5 (3,2)
Age (years) 56 ± 4 63 ± 5 55 ± 5 64 ± 2 56 ± 1
Height (cm) 177 ± 3 170 ± 4 172 ± 5 167 ± 4 172 ± 5
Weight (kg) 80 ± 10 83 ± 13 77 ± 9 82 ± 8 86 ± 10
DXA body fat (%) 32 ± 4 37 ± 3 33 ± 7 30 ± 4 32 ± 5
Lean body mass (kg) 54 ± 6 52 ± 8 51 ± 7 57 ± 5 58 ± 7
Body mass Index (kg/m2) 25 ± 2 28 ± 3 26 ± 3 29 ± 2 29 ± 2
Fat-free index (kg/m2) 17 ± 1 18 ± 2 17 ± 2 20 ± 1 19 ± 1
Lean body mass (DXA) (kg) 49 ± 7 51 ± 7 48 ± 7 53 ± 5 54 ± 6
Thigh mass (DXA) (kg) 16 ± 2 13 ± 2 16 ± 2 15 ± 1 16 ± 2
Medication      
No prescribed meds 0% 0% 100% 14% 60%
AAT Augmentation Therapy 100% 0% 0% 0% 0%
Bronchodilator 100% 100% 0% 86% 0%
Inhaled corticosteriods 83% 83% 0% 71% 0%
Oxygen 33% 0% 0% 29% 0%
Diuretics 0% 17% 0% 14% 0%
Anti-inflammatory 0% 0% 0% 0% 0%
Anti-depressive 0% 17% 0% 29% 0%
β-blockers 33% 33% 0% 29% 40%
Serum liver function tests      
Total Bilirubin (mg/dL) 0.48 ± 0.06 0.50 ± 0.12 0.45 ± 0.09 0.37 ± 0.05 0.51 ± 0.12
Albumin (g/dL) 3.80 ± 0.17 3.45 ± 0.15 3.80 ± 0.12 3.77 ± 0.11 3.82 ± 0.06
Alanine Aminotransferase (U/L) 42.3 ± 15.2 28.5 ± 3.4 41.0 ± 12.7 23.4 ± 5.3 30.6 ± 2.9
Serum AAT level (mg/dl) 96 ± 22b,c <20 ± 0a,d,e <20 ± 0a,d,e 113 ± 11b,c 109 ± 12b,c
  1. Data are mean ± SE. AATD, alpha-1 antitrypsin deficient; AUG, augmentation therapy; PFTnorm, pulmonary function testing normal; AAT, alpha-1 antitrypsin; COPD, chornic obstructive pulmonary disease; DXA, dual-energy x-ray absorptiometry; m, male; f, female; Significance difference between group is denoted as follows, ‘a’ different that AATD + AUG, ‘b’ different that AATD-AUG, ‘c’ different compared to AATD PDTnorm, ‘d’ different compared to COPD, ‘e’ different compared to Healthy. In all cases, significance is p ≤ 0.05.