Seasonal variation of serum KL-6 concentrations is greater in patients with hypersensitivity pneumonitis

BMC Pulmonary Medicine

Table 2 Diagnostic value of KL-6 concentrations and KL-6 ratios for the diagnosis of hypersensitivity pneumonitis (HP), House-HP, and Bird-HP

Comparison	Variables	AUC	Pvalue	Youden’s index	Cut-off value	Sensitivity (%)	Specificity (%)	Diagnostic accuracy (%)	Likelihood ratio
HP vs non-HP	Kmax	0.681	0.017	0.316	2532	44.4	87.2	79.2	3.47
	Kmax-Kmin	0.744	0.001	0.427	654	88.9	53.8	60.4	1.93
	Kmax/Kmin	0.757	0.001	0.436	3.15	66.7	76.9	75.0	2.89
House-HP vs non-House-HP	Smax-Wmax	0.774	0.007	0.472	196	66.7	80.5	79.1	3.42
House-HP vs non-House-HP	Smax/Wmax	0.802	0.003	0.461	1.08	77.8	68.3	69.2	2.45
Bird-HP vs non-Bird-HP	Smax-Wmax	0.842	0.001	0.706	-328	88.9	81.7	82.4	4.86
Bird-HP vs non-Bird-HP	Smax/Wmax	0.878	<0.001	0.705	0.61	77.8	92.7	91.2	10.63

Cut-off value of Smax-Wmax and Smax/Wmax for the diagnosis of Bird-HP was less than -328 and 0.61, respectively. AUC; area under the curve.

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