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Table 3 Regression analysis: linear mixed models

From: Health-related quality of life and chronic obstructive pulmonary disease in early stages – longitudinal results from the population-based KORA cohort in a working age population

Effect

Physical component: PCS-12

Mental component: MCS-12

Basic model

Extended model

Basic model

Extended model

No COPD

ref.

ref.

ref.

ref.

COPD grade 1

−1.10

−1.10

−0.10

0.16

COPD grade 2+

−3.54**

−3.98**

1.24

1.36

Time (1, F4L)*no COPD

ref.

ref.

ref.

ref.

Time (1, F4L)*COPD grade 1

0.15

−0.26

−0.66

−0.94

Time (1, F4L)*COPD grade 2+

−1.16

−1.08

−0.75

−0.71

Time (−1, S4)*no COPD

ref.

ref.

ref.

ref.

Time (−1, S4)*COPD grade 1

−0.06

−0.18

−0.12

−0.12

Time (−1, S4)*COPD grade 2+

0.27

0.65

−0.23

−0.02

Time (0, F4)

ref.

ref.

ref.

ref.

Time (−1, S4)

0.32

0.08

−0.08

−0.09

Time (1, F4L)

−0.33

−0.15

0.73*

0.77*

Age 41–45 yrs.

ref.

ref.

ref.

ref.

Age 46–50 yrs.

0.48

0.51

0.83

0.81

Age 51–55 yrs.

−1.04

−0.62

0.27

0.29

Age ≥ 56 yrs.

−2.94***

−2.42***

0.66

0.68

Sex: male

ref.

ref.

ref.

ref.

Sex: female

−0.78*

−1.00**

−2.33***

−2.48***

Educational level:

    

Basic education

ref.

ref.

ref.

ref.

Secondary education

1.61***

1.20**

−0.66

−0.70

High education

2.40***

1.85***

−0.29

−0.44

Smoking status:

    

Never smoker

 

ref.

 

ref.

Current smoker

 

−0.82*

 

−1.05*

Former smoker

 

−0.92

 

−0.56

BMI:

    

Normal (18.5 ≤ BMI < 25)

 

ref.

 

ref.

Underweight (BMI < 18.5)

 

−0.60

 

−1.75

Overweight (25 ≤ BMI < 30)

 

−0.48

 

−0.34

Obese (BMI > 30)

 

−2.48***

 

0.25

Comorbidities:

    

Heart failure

 

−4.94***

 

−2.75*

Myocardial infarction

 

−3.33*

 

0.77

Stroke

 

−5.58***

 

−4.03*

Cancer

 

−3.21***

 

0.28

Diabetes

 

−1.72*

 

−2.05*

Intercept

49.12

50.64

51.71

52.26

  1. *p < 0.05, **p < 0.01, ***p < 0.001.
  2. S4: −7 years, F4: baseline, F4L: +3 years.