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Table 4 Interactions between maternal perinatal anxiety (STAI score) and copy number variation of GSTT1 on the development of respiratory tract infection during the first year of life

From: The effect of perinatal anxiety on bronchiolitis is influenced by polymorphisms in ROS-related genes

 

URTI*

LRTI†

Bronchiolitis

STAI

GSTT1

URTI diagnosis (-), n

URTI diagnosis (+), n

aOR‡(95% CI)

LRTI diagnosis (-), n

LRTI diagnosis (+), n

aOR‡(95% CI)

Bronchiolitis diagnosis (-), n

Bronchiolitis diagnosis (+), n

aOR‡(95% CI)

low (≤41)

CNV ≥ 1

16

76

1

82

10

1

85

7

1

low (≤41)

CNV = 0

37

76

0.43 (0.21–0.88)

102

11

0.86 (0.33–2.21)

104

9

0.97 (0.33–2.83)

high (>41)

CNV ≥ 1

22

65

0.66 (0.30–1.45)

75

12

1.29 (0.50–3.33)

79

8

1.13 (0.37–3.34)

high (>41)

CNV = 0

22

77

1.02 (0.46–2.26)

77

22

2.47 (1.04–5.89)

80

19

2.79 (1.05–7.43)

  1. aOR, adjusted odds ratio; CI, confidence interval; CNV, copy number variation; GSTT1, glutathione S-transferase T1; LRTI, lower respiratory tract infection; RTI, respiratory tract infection; URTI, upper respiratory tract infection; STAI, State-Trait Anxiety Inventory.
  2. *URTI includes common colds, sinusitis, otitis media, and croup.
  3. †LRTI includes pneumonia, tracheobronchitis, and bronchiolitis.
  4. ‡Adjusted for infant’s sex, season of birth, maternal age, education level, prenatal exposure to tobacco smoking, history of any maternal allergic diseases and history of any paternal allergic diseases (atopic dermatitis, allergic rhinitis, or asthma).
  5. The subject number of this analysis is different from those in Table 3 due to the failure of simultaneous genotyping of GSTP1 (rs1695) and GSTT1 in several subjects.
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BMC Pulmonary Medicine

ISSN: 1471-2466

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