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Table 3 Genotype frequencies of selected SNPs in controls and children with bronchospasm a

From: Genetic polymorphisms and risk of recurrent wheezing in pediatric age

  Observed Expected      
Gene and polymorphic alleles Control group (n = 119) Children with wheezing (n = 119) Control group (n = 119) Children with wheezing (n = 119) HWE, χ 2controls HWE, χ 2wheezing    
  N % N % N % N % p-value p-value ORb 95% CI p-valuec
IL8-rs4073              
A 28 23.7 21 17.8 22.5 19.0 20.8 17.6    1.00 (Reference) -
A/T 47 39.8 57 48.3 58.0 49.2 57.5 48.7    2.50 (1.15-5.44) 0.02
T 43 36.4 40 33.9 37.5 31.8 39.8 33.7 0.04 0.93 1.57 (0.71-3.45) 0.27
VEGFA-rs833058              
C 32 27.1 22 18.5 32.6 27.6 28.3 23.8    1.00 (Reference) -
C/T 60 50.9 72 60.5 58.8 49.9 59.5 50.0    2.22 (1.09-4.55) 0.03
T 26 22.0 25 21.0 26.6 22.5 31.3 26.3 0.83 0.02 1.96 (0.83-4.65) 0.13
MBL2-rs1800450              
C 87 73.7 76 63.9 87.3 74.0 77.4 65.1    1.00 (Reference) -
C/T 29 24.6 40 33.6 28.4 24.1 37.1 31.2    1.90 (1.01-3.58) 0.05
T 2 1.7 3 2.5 2.3 2.0 4.4 3.7 0.81 0.40 1.03 (0.15-7.23) 0.97
IKBKB-rs3747811              
A 36 31.3 20 17.1 28.3 24.6 24.5 20.9    1.00 (Reference) -
A/T 42 36.5 67 57.3 57.5 50.0 58.1 49.6    3.26 (1.55-6.85) 0.0018
T 37 32.2 30 25.6 29.3 25.4 34.5 29.5 0.004 0.10 2.01 (0.89-4.53) 0.09
CTLA4-rs3087243              
A 25 21.2 35 29.7 32.1 27.2 35.8 30.3    1.00 (Reference) -
A/G 73 61.9 60 50.9 58.9 49.9 58.4 49.5    0.50 (0.25-0.99) 0.05
G 20 17.0 23 19.5 27.1 22.9 23.8 20.2 0.009 0.76 0.65 (0.27-1.56) 0.34
NFKBIB-rs3136641              
C 64 54.2 72 61.0 59.8 50.7 71.0 60.1    1.00 (Reference) -
C/T 40 33.9 39 33.1 48.4 41.0 41.1 34.8    0.90 (0.49-1.66) 0.73
T 14 11.9 7 5.9 9.8 8.3 6.0 5.0 0.06 0.58 0.33 (0.11-0.94) 0.04
  1. aThe sums may not add up to the total because of a few missing values; bOdds ratios adjusted for age (< / ≥ 2 years). cp-values from univariate analyses, not adjusted for multiple testing. None of the p-values was significant after correction for multiple testing.
  2. HWE Hardy-Weinberg equilibrium, NE Not estimable.