Genetic polymorphisms and risk of recurrent wheezing in pediatric age

BMC Pulmonary Medicine

Table 3 Genotype frequencies of selected SNPs in controls and children with bronchospasm ^a

	Observed				Expected
Gene and polymorphic alleles	Control group (n = 119)		Children with wheezing (n = 119)		Control group (n = 119)		Children with wheezing (n = 119)		HWE, χ ²controls	HWE, χ ²wheezing
	N	%	N	%	N	%	N	%	p-value	p-value	OR^b	95% CI	p-value^c
IL8-rs4073
A	28	23.7	21	17.8	22.5	19.0	20.8	17.6			1.00	(Reference)	-
A/T	47	39.8	57	48.3	58.0	49.2	57.5	48.7			2.50	(1.15-5.44)	0.02
T	43	36.4	40	33.9	37.5	31.8	39.8	33.7	0.04	0.93	1.57	(0.71-3.45)	0.27
VEGFA-rs833058
C	32	27.1	22	18.5	32.6	27.6	28.3	23.8			1.00	(Reference)	-
C/T	60	50.9	72	60.5	58.8	49.9	59.5	50.0			2.22	(1.09-4.55)	0.03
T	26	22.0	25	21.0	26.6	22.5	31.3	26.3	0.83	0.02	1.96	(0.83-4.65)	0.13
MBL2-rs1800450
C	87	73.7	76	63.9	87.3	74.0	77.4	65.1			1.00	(Reference)	-
C/T	29	24.6	40	33.6	28.4	24.1	37.1	31.2			1.90	(1.01-3.58)	0.05
T	2	1.7	3	2.5	2.3	2.0	4.4	3.7	0.81	0.40	1.03	(0.15-7.23)	0.97
IKBKB-rs3747811
A	36	31.3	20	17.1	28.3	24.6	24.5	20.9			1.00	(Reference)	-
A/T	42	36.5	67	57.3	57.5	50.0	58.1	49.6			3.26	(1.55-6.85)	0.0018
T	37	32.2	30	25.6	29.3	25.4	34.5	29.5	0.004	0.10	2.01	(0.89-4.53)	0.09
CTLA4-rs3087243
A	25	21.2	35	29.7	32.1	27.2	35.8	30.3			1.00	(Reference)	-
A/G	73	61.9	60	50.9	58.9	49.9	58.4	49.5			0.50	(0.25-0.99)	0.05
G	20	17.0	23	19.5	27.1	22.9	23.8	20.2	0.009	0.76	0.65	(0.27-1.56)	0.34
NFKBIB-rs3136641
C	64	54.2	72	61.0	59.8	50.7	71.0	60.1			1.00	(Reference)	-
C/T	40	33.9	39	33.1	48.4	41.0	41.1	34.8			0.90	(0.49-1.66)	0.73
T	14	11.9	7	5.9	9.8	8.3	6.0	5.0	0.06	0.58	0.33	(0.11-0.94)	0.04

^aThe sums may not add up to the total because of a few missing values; ^bOdds ratios adjusted for age (< / ≥ 2 years). ^cp-values from univariate analyses, not adjusted for multiple testing. None of the p-values was significant after correction for multiple testing.
HWE Hardy-Weinberg equilibrium, NE Not estimable.

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