Clinical significance of mTOR, ZEB1, ROCK1 expression in lung tissues of pulmonary fibrosis patients

BMC Pulmonary Medicine

Table 2 Comparisons of clinical characteristics between idiopathic pulmonary fibrosis and connective tissue disease related interstitial lung disease of histologic usual interstitial pneumonia pattern

	IPF	CTD-ILD	p value
	(n = 26)	(n = 4)
Age, years, median (range)	62 (38-74)	52 (48-55)	0.139
Male sex	14 (53.8)	0	0.066
Ever smoker	11 (42.3)	0	0.141
Pulmonary function test
FVC, %	73.4 ± 15.6	78.0 ± 15.9	0.746
FEV₁, %	85.4 ± 16.3	85.0 ± 17.9	0.837
DL_CO, %	62.8 ± 28.8	65.7 ± 22.2	0.825
Histologic fibrosis score	12.9 ± 8.0	8.6 ± 12.9	0.220
Radiologic honeycombing score	2.1 ± 1.9	1.5 ± 1.9	0.791
mTOR expression score	4.4 ± 2.8	2.7 ± 4.2	0.245
ZEB1 expression score	3.2 ± 2.6	2.5 ± 3.0	0.576
ROCK1 expression score	3.4 ± 2.9	1.7 ± 1.7	0.359
Steroids or immunosuppressive treatment	12 (46.2)	4 (100)	0.089

Definition of abbreviations: IPF = idiopathic pulmonary fibrosis, CTD-ILD = connective tissue disease related interstitial lung disease, FVC = forced vital capacity, FEV₁ = forced expiratory volume in 1 s, DL_CO = carbon monoxide diffusion capacity.
Data are presented as mean ± SD or numbers (%).

ISSN: 1471-2466