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Figure 6 | BMC Pulmonary Medicine

Figure 6

From: Upregulation of activin-B and follistatin in pulmonary fibrosis – a translational study using human biopsies and a specific inhibitor in mouse fibrosis models

Figure 6

Effect of activin inhibition by sActRIIB-Fc in asbestos (Asb)- and silica-exposed mice (A). Fibrosis-related genes collagen (Col1A1, Col3A1), smooth muscle actin (Sma), fibronectin (Fn), and tenascin-C (Tnc) relative mRNA levels are shown in B. Lung total hydroxyproline (HYP) levels (C) did not show any significant alterations between groups treated with sActRIIB-Fc and the non-treated control. P values from Kruskal-Wallis (comparing three groups) and Mann-Whitney U test (comparing two groups) are indicated in the figure.

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BMC Pulmonary Medicine

ISSN: 1471-2466

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