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Table 4 Summary of SP-A and SP-D immunolocalization in normal peripheral and IPF lungs

From: Distinct compartmentalization of SP-A and SP-D in the vasculature and lungs of patients with idiopathic pulmonary fibrosis

  SP-A SP-D
Type II alveolar epithelial cells (in normal lungs) + +
Columnar ciliated cells - -
Regenerated type II alveolar epithelial cells ++ ++
Fibrous parenchyma - ~ + - ~ ±
Mucus in honeycomb cysts +++ - ~ ±
Inside small vessels - - ~ +
Elastic fibers in the wall of blood vessels + -
  1. Immunostaining intensity: -, (none); ±, (more or less); +, (positive); ++, (more intense); and +++, (very intense). SP-A, surfactant protein A; SP-D, surfactant protein D; IPF, idiopathic pulmonary fibrosis.