Distinct compartmentalization of SP-A and SP-D in the vasculature and lungs of patients with idiopathic pulmonary fibrosis

Table 4 Summary of SP-A and SP-D immunolocalization in normal peripheral and IPF lungs

	SP-A	SP-D
Type II alveolar epithelial cells (in normal lungs)	+	+
Columnar ciliated cells	-	-
Regenerated type II alveolar epithelial cells	++	++
Fibrous parenchyma	- ~ +	- ~ ±
Mucus in honeycomb cysts	+++	- ~ ±
Inside small vessels	-	- ~ +
Elastic fibers in the wall of blood vessels	+	-

Immunostaining intensity: -, (none); ±, (more or less); +, (positive); ++, (more intense); and +++, (very intense). SP-A, surfactant protein A; SP-D, surfactant protein D; IPF, idiopathic pulmonary fibrosis.

ISSN: 1471-2466