The longitudinal relationship of changes of adiposity to changes in pulmonary function and risk of asthma in a general adult population

Table 4 Five-year changes of FEV (ml) and FVC (ml) in non-atopic and atopic individuals (upper panel), and in individuals with or without elevated FeNO-levels (lower panel), per one standard deviation increase of adiposity measures

	Est (ml)	Se (ml)	P	Est (ml)	Se (ml)	P	p-i
	Non-atopic			Atopic
FEV1
Weight (1 sd)	−46.0	4.2	<.001	−46.2	8.5	<.001	ns
BMI (1 sd)	−42.3	4.2	<.001	−47.0	8.6	<.001	ns
WC (1 sd)	−38.9	4.3	<.001	−43.1	8.3	<.001	ns
FatP (1 sd)	−30.6	4.3	<.001	−35.8	8.5	<.001	ns
FVC
Weight (1 sd)	−65.5	6.5	<.001	−59.3	13.1	<.001	ns
BMI (1 sd)	−61.6	6.6	<.001	−54.8	13.2	<.001	ns
WC (1 sd)	−53.2	6.6	<.001	−48.6	12.8	<.001	ns
Fat (1 sd)	−32.3	6.7	<.001	−32.1	13.1	<.02	ns
	Normal FeNO (<=20 ppb)			Elevated FeNO (>20 ppb)
FEV1
Weight (1 sd)	−45.6	4.7	<.001	−48.7	7.6	<.001	ns
BMI (1 sd)	−43.4	4.7	<.001	−43.9	7.7	<.001	ns
WC (1 sd)	−43.3	4.8	<.001	−31.7	7.2	<.001	ns
FatP (1 sd)	−31.8	4.8	<.001	−24.3	7.4	<.001	ns
FVC
Weight (1 sd)	−57.1	7.2	<.001	−85.2	12.6	<.001	0.04
BMI (1 sd)	−54.5	7.2	<.001	−78.5	12.8	<.001	ns
WC (1 sd)	−48.1	7.5	<.001	−59.4	11.9	<.001	ns
FatP (1 sd)	−32.2	7.5	<.001	−28.1	12.4	<.02	ns

Linear regression models fitted with interaction between adiposity measure and either atopy or elevated FeNO and adjusted for age, atopy, and smoking (pack years); p-i, p-values for interaction test. Est, beta-estimate; Se, standard error of Est; p, p-value; Atopy defined as serum specific IgE positivity (> = .35 kU/l) to inhalant allergens; FeNO, fractional expiratory nitric oxide;1 sd, one standard deviation; ns, non-significant; BMI, body mass index; WC, waist circumference; FatP, fat percentage.

ISSN: 1471-2466