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Table 2 Biomarker patterns in plasma

From: Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation

Biomarker

Non-sensitized

OVA-sensitized

N6022 0.1 mg/kg

N6022 1 mg/kg

Fibrinogen

74540.0 ± 5605.7*

126250.0 ± 11070.8

32240.0 ± 7486.6*

68560.0 ± 4251.7*

Haptoglobin

22.0 ±4.3*

103.8 ±11.6*

43.4 ±13.8*

33.8 ±8.4*

IgA

366.2 ± 14.6*

236.8 ±10.0

347.2 ±14.8*

344.2 ±11.3*

IL-5

1.1 ±0.1*

2.3 ±0.3*

1.2 ±0.2*

1.0 ± 0.1*

IL-18

45.4 ±1.6*

63.0 ±2.1

51.4 ±6.5

50.6 ±2.4*

  1. Plasma biomarker levels were determined using a multi-analyte profile of biomarker patterns. Values are the means ± SEM (N = 5) in either μg/mL (Fibrinogen, Haptoglobin, and IgA) or ng/mL (IL-5 and IL-18).
  2. *p < 0.05 vs. OVA-sensitized, One-way ANOVA, Dunnett’s.
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BMC Pulmonary Medicine

ISSN: 1471-2466

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