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Table 3 Correlation between markers assessed 2006/2007 and the decline in lung function

From: Potential prognostic value of biomarkers in lavage, sputum and serum in a five year clinical follow-up of smokers with and without COPD

 

FEV1(L)

FEV1(%pred.)

FEV1/FVC (%)

 

All

COPD smokers

Healthy smokers

All

COPD smokers

Healthy smokers

All

COPD smokers

Healthy smokers

BAL:

         

Calprotectin

      

−0.53**

  

IL8

        

−0.72*

IS:

         

MMP7

 

−0.6

 

−0.53*

−0.62

 

−0.58**

−0.73**

 

MMP9

       

−0.66*

 

MMP9/TP

       

−0.65*

 

A1AT

  

−0.72

  

−0.75

   

HSA

  

−0.84**

  

−0.88**

   

IL-6

     

−0.76

   

Serum:

         

IGF2

 

0.74***

  

0.72**

  

0.78***

 

Leptin

 

0.72**

  

0.7**

  

0.75***

 

Creatinine

  

−0.65

      

Blood:

         

ALP

    

0.65*

    

HCT

  

−0.77**

  

−0.82***

   

HGB

  

−0.78***

  

−0.80***

   

RBC

  

−0.8***

  

−0.79***

   

Monocytes

        

−0.74*

  1. Only significant correlations are displayed and are either p < 0.05, or as marked: *p < 0.02, **p ≤ 0.01, ***p ≤ 0.005.
  2. BAL = bronchial alveolar lavage, IS = induced sputum, Calprot. = Calprotectin, HSA = human serum albumin, HCT = hematocrit, HGB = hemoglobin, MMP = matrix metalloproteinase, RBC = red blood cells, ALP: Alkaline phosphatase. A negative correlation means that a stronger decline in lung function over the 5 year period is associated with higher levels of the respective parameter (e.g. sputum MMP7). A positive correlation indicates that lower levels of the respective parameter are associated with a stronger decline in lung function (e.g. IGF2).
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BMC Pulmonary Medicine

ISSN: 1471-2466

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