Table 5 Positive predictive value of claims for asthma, COPD, both or neither in the 6 months prior to initiation of a long-acting beta agonist, overall and stratified by clinically-defined covariates
Number of confirmed cases | Medical records received | Positive predictive value (%) | 95% CI (%) | |
|---|---|---|---|---|
Claim for asthma only | ||||
Medications | ||||
Previous LABA | 7 | 8 | 87.5 | 47.3, 99.7 |
Previous ICS | 12 | 14 | 85.7 | 57.2, 98.2 |
Inhaled anticholinergics | 0 | 0 | 0.0 | N/A |
Systemic corticosteroids | 31 | 40 | 77.5 | 61.5, 89.2 |
Leukotriene modifiers | 24 | 30 | 80.0 | 61.4, 92.3 |
Xanthine inhibitors | 3 | 3 | 100.0 | 29.2, 100.0 |
Prescriber Specialty | ||||
Family/general provider | 36 | 48 | 75.0 | 60.4, 86.4 |
Allergy/immunology | 15 | 20 | 75.0 | 51.0, 91.3 |
Internal medicine | 30 | 42 | 71.4 | 55.4, 84.3 |
Pulmonology | 13 | 17 | 76.5 | 50.1, 93.2 |
Diagnoses | ||||
Upper respiratory tract infections | 40 | 49 | 81.6 | 68.0, 91.2 |
Lower respiratory tract infection | 67 | 91 | 73.6 | 63.3, 82.3 |
Bronchitis/Bronciolitis | 19 | 24 | 79.2 | 57.8, 93.0 |
Spirometry procedure | 26 | 33 | 78.8 | 61.1, 91.0 |
Claim for COPD Only | ||||
Medications | ||||
Previous LABA | 3 | 5 | 60.0 | 14.7, 94.7 |
Previous ICS | 4 | 4 | 100.0 | 39.8, 100.0 |
Inhaled anticholinergics | 33 | 35 | 94.3 | 80.8, 99.3 |
Systemic corticosteroids | 29 | 36 | 80.6 | 64.0, 91.8 |
Leukotriene modifiers | 5 | 9 | 55.6 | 21.2, 86.3 |
Xanthine inhibitors | 2 | 2 | 100.0 | 16.8, 100.0 |
Prescriber Specialty | ||||
Family/general provider | 40 | 48 | 83.3 | 69.8, 92.5 |
Allergy/immunology | 0 | 3 | 0.0 | 0.0, 70.6 |
Internal medicine | 34 | 42 | 81.0 | 65.9, 91.4 |
Pulmonology | 29 | 32 | 90.6 | 75.0, 98.0 |
Diagnoses | ||||
Upper respiratory tract infections | 12 | 20 | 60.0 | 36.1, 80.9 |
Lower respiratory tract infection | 75 | 92 | 81.5 | 72.1, 88.9 |
Bronchitis/Bronciolitis | 51 | 59 | 86.4 | 75.0, 94.0 |
Spirometry procedure | 32 | 39 | 82.1 | 66.5, 92.5 |
Claim for asthma and COPD (PPV of asthma only) | ||||
Medications | ||||
Previous LABA | 3 | 12 | 25.0 | 5.5, 57.2 |
Previous ICS | 4 | 14 | 28.6 | 8.4, 58.1 |
Inhaled anticholinergics | 9 | 39 | 23.1 | 11.1, 39.3 |
Systemic corticosteroids | 27 | 70 | 38.6 | 27.1, 51.0 |
Leukotriene modifiers | 10 | 30 | 33.3 | 17.3, 52.8 |
Xanthine inhibitors | 2 | 6 | 33.3 | 4.3, 77.7 |
Prescriber Specialty | ||||
Family/general provider | 22 | 67 | 32.8 | 21.8, 45.4 |
Allergy/immunology | 7 | 10 | 70.0 | 34.8, 93.3 |
Internal medicine | 25 | 59 | 42.4 | 29.6, 55.9 |
Pulmonology | 19 | 52 | 36.5 | 23.6, 51.0 |
Diagnoses | ||||
Upper respiratory tract infections | 20 | 43 | 46.5 | 31.2, 62.3 |
Lower respiratory tract infection | 40 | 104 | 38.5 | 29.1, 48.5 |
Bronchitis/Bronciolitis | 28 | 72 | 38.9 | 27.6, 51.1 |
Spirometry procedure | 21 | 53 | 39.6 | 26.5, 54.0 |
No claims for asthma or COPD (PPV of asthma only) | ||||
Medications | ||||
Previous LABA | 0 | 4 | 0.0 | 0.0, 60.2 |
Previous ICS | 0 | 2 | 0.0 | 0.0, 84.2 |
Inhaled anticholinergics | 0 | 2 | 0.0 | 0.0, 84.2 |
Systemic corticosteroids | 9 | 28 | 32.1 | 15.9, 52.4 |
Leukotriene modifiers | 5 | 11 | 45.5 | 16.7, 76.6 |
Xanthine inhibitors | 0 | 0 | 0.0 | N/A |
Prescriber specialty | ||||
Family/general provider | 12 | 48 | 25.0 | 13.6, 39.6 |
Allergy/immunology | 1 | 1 | 100.0 | 2.5, 100.0 |
Internal medicine | 7 | 28 | 25.0 | 10.7, 44.9 |
Pulmonology | 3 | 7 | 42.9 | 9.9, 81.6 |
Diagnoses | ||||
Upper respiratory tract infections | 5 | 30 | 16.7 | 5.6, 34.7 |
Lower respiratory tract infection | 6 | 33 | 18.2 | 7.0, 35.5 |
Bronchitis/Bronchiolitis | 5 | 29 | 17.2 | 5.8, 35.8 |
Spirometry procedure | 3 | 8 | 37.5 | 8.5, 75.5 |