Table 4 Subgroup analysis for sensitivity and specificity

Publication year

0.90 (95% CI 0.84-0.94)

2.19

0.84

0.40

0.97 (95% CI 0.92-0.99)

3.39

0.93

0.35

Method

0.88 (95% CI 0.83-0.92)

2.01

−0.20

0.84

0.96 (95% CI 0.92-0.98)

3.07

−0.10

0.92

Cut-off value

0.86 (95% CI 0.80-0.91)

1.85

−0.96

0.34

0.96 (95% CI 0.91-0.98)

3.08

−0.02

0.99

QUADAS score

0.89 (95% CI 0.84-0.93)

2.07

0.34

0.74

0.98 (95% CI 0.95-0.99)

3.77

3.15

0.00

Sample size

0.87 (95% CI 0.82-0.91)

1.92

−1.03

0.30

0.95 (95% CI 0.91-0.98)

3.02

−0.36

0.72

Prospective

0.90 (95% CI 0.85-0.93)

2.18

1.08

0.28

0.95 (95% CI 0.90-0.98)

2.95

−0.64

0.52

Design

0.90 (95% CI 0.86-0.93)

2.22

1.70

0.09

0.94 (95% CI 0.90-0.97)

2.81

−1.42

0.16

Consecutive

0.87 (95% CI 0.82-0.91)

1.90

−1.50

0.13

0.95 (95% CI 0.91-0.97)

2.87

−1.56

0.12

Blinding

0.88 (95% CI 0.80-0.93)

1.99

−0.16

0.88

0.98 (95% CI 0.95-0.99)

3.95

2.00

0.05