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Table 2 Hemodynamic and IVUS data of control subjects and patients with PAH at rest and during stress maneuver

From: Impairment of pulmonary vascular reserve and right ventricular systolic reserve in pulmonary arterial hypertension

 

PAH patients (n = 18)

Control patients (n = 10)

 

Rest

Stress

Rest

Stress

CO, L/min

4.0 ± 0.3

5.6 ± 0.4§

4.7 ± 0.1

8.6 ± 0.2*§

HR, bpm

76 ± 3

104 ± 3.6§

73 ± 1.3

114 ± 1.5*§

SV, mL

55 ± 5.1

55 ± 2.2

64.5 ± 1.4

78 ± 2*§

mPAP, mm Hg

52 ± 4

61 ± 5§

15 ± 2*

18 ± 1.2*§

pPAP, mm Hg

49 ± 21

65 ± 6§

11 ± 3*

15 ± 1.1*§

PCWP, mm Hg

10.3 ± 1.0

7.3 ± 0.9

8.8 ± 0.6

11 ± 0.7

RAP, mm Hg

7.4 ± 0.9

7.7 ± 0.9

5.0 ± 1.2

6.5 ± 1.1

PVR, Wood units

12 ± 1.7

11.4 ± 1.9

3 ± 0.3*

1.9 ± 0.17*§

PC, mL/mm Hg

1.5 ± 0.26

1.1 ± 0.2§

6.2 ± 0.4*

5.5 ± 0.6*

TPR, Wood units

14.8 ± 1.9

13.1 ± 2.0§

3.3 ± 0.25

2.1 ± 0.16*§

IVUSp, %

33 ± 4.8

27 ± 4

52 ± 2.5*

85 ± 3.4*§

EM, mm Hg

184 ± 25

275 ± 36§

21 ± 1.9*

18 ± 1.7*§

  1. *p < 0.05 between both groups in the same condition; §p < 0.05 between both conditions in the same group.
  2. CO: cardiac output; PC: pulmonary capacitance index; EM: elastic modulus; HR: heart rate; IVUSp: pulmonary arterial pulsatility; mPAP and pPAP: mean and pulse arterial pulmonary pressures; PCWP: pulmonary capillary wedge pressure; PVR: pulmonary vascular resistance; RAP: right atrial pressure; SV: stroke volume; TPR: total pulmonary resistance.