Skip to main content

Table 2 The inhibitory effect of anti-CD137 blocking antibody (10 μg/mL) (a137), 10 -6 M methylprednisolone (MP) alone and in combination on granzyme B, IFNγ and TNFα expression by CD28null(28-) and CD28 + (28+) CD8+ T cells following stimulation (mean ± SEM of 8 experiments) compared with control antibody

From: Targeting peripheral blood pro-inflammatory cytotoxic lymphocytes by inhibiting CD137 expression: novel potential treatment for COPD

 

Granzyme B

IFNγ

TNFα

 

CD8+

CD8+

CD8+

 

28-

28+

28-

28+

28-

28+

a137

26 ± 4*

17 ± 3

28 ± 3*

21 ± 2

31* ± 5

23 ± 2

MP

2 ± 1

5 ± 2

2 ± 1

5 ± 2

1 ± 1

4 ± 2

a137 + MP

29 ± 3#

21 ± 3#

31 ± 3#

26 ± 3#

32 ± 3#

27 ± 3#

  1. *The percentage inhibition of granzyme B, IFNγ and TNFα by CD28- and CD28+T cells compared with control (same specimen) without treatment/s.
  2. The inhibitory effect of anti-CD137 was greater than for MP for granzyme B, IFNγ and TNFα in all T-cell subsets (p < 0.05 for all).
  3. *The inhibitory effect of anti-CD137 was greater than for the CD28nullCD8+ subset than for the CD28 + CD8+ subset for granzyme B, IFNγ and TNFα (p < 0.05 for all).
  4. #The combination of anti-CD137 and 10-6 M methylprednisolone resulted in the additive inhibition of granzyme B, IFNγ and TNFα expression in CD28null and CD28+ CD8+ T cells.
Back to article page

BMC Pulmonary Medicine

ISSN: 1471-2466

Contact us