Demographic, clinical, and laboratory parameters of cystic fibrosis during the last two decades: a comparative analysis

Table 2 Presence of digestive symptoms, comorbidities, and percentiles for weight and height in patients with cystic fibrosis in a Brazilian referral center during the decades of 1990 to 2000 and 2000 to 2010

Decade	Onset of digestive symptoms			p-value	OR	95% CI
Decade	Presence	Absence	Total	p-value	OR	95% CI
1990–2000	62 (59.6%)	42 (40.4%)	104	<0.001	0.295	0.17–0.51
2000–2010	151 (83.4%)	30 (16.6%)	181	<0.001	1	–
Decade	Meconium ileus			p	OR	95%CI
Decade	Presence	Absence	Total	p	OR	95%CI
1990–2000	6 (5.8%)	98 (94.2%)	104	0.021	0.35	0.11–0.91
2000–2010	27 (14.9%)		181	0.021	1	–
Decade	Diabetes mellitus			p	OR	95%CI
Decade	Presence	Absence	Total	p	OR	95%CI
1990–2000	5 (4.8%)	99 (95.2%)	104	0.001	0.228	0.07–0.61
2000–2010	33 (18.2%)	148 (81.8%)	181	0.001	1	–
Decade	Fecal fat balance			p	OR	95%CI
Decade	Presence	Absence	Total	p	OR	95%CI
1990–2000	71 (68.3%)	33 (31.7%)	104	0.031	0.534	(0.31–0.93)
2000–2010	145 (80.1%)	36 (24.2%)	181	0.031	1	–
Decade	Weight percentile			p	OR	95%CI
Decade	P < 10	P ≥ 10	Total	p	OR	95%CI
1990–2000	73 (70.2%)	31 (29.8%)	104	<0.001	4.206	2.34–7.67
2000–2010	35 (35.9%)	63 (64.1%)	98	<0.001	1	–
Decade	Height percentile			p	OR	95%CI
Decade	P < 10	P ≥ 10	Total	p	OR	95%CI
1990–2000	59 (56.7%)	45 (43.3%)	104	0.025	1.895	1.08–3.34
2000–2010	40 (40.9%)	58 (59.1%)	98		1	–

P – percentile; p – p-value; OR – odds ratio; CI – confidence interval. Statistical analysis was performed by the χ² test. Statistically significant values are indicated by bold font.

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