Phenotypic and genetic heterogeneity in a genome-wide linkage study of asthma families

Altmüller, Janine; Seidel, Corinna; Lee, Young-Ae; Loesgen, Sabine; Bulle, Dieter; Friedrichs, Frank; Jellouschek, Heidemarie; Kelber, Julika; Keller, Angela; Schuster, Antje; Silbermann, Michael; Wahlen, Wolfgang; Wolff, Peter; Schlenvoigt, Gerhard; Rüschendorf, Franz; Nürnberg, Peter; Wjst, Matthias

doi:10.1186/1471-2466-5-1

BMC Pulmonary Medicine

Table 4 Linkage results in 201 core families with at least 2 children having asthma. Weak linkage (p < 0.01) and suggestive linkage (p = 0.0007) is indicated in bold.

From: Phenotypic and genetic heterogeneity in a genome-wide linkage study of asthma families

GDB	PIC	Chr.	cM (Marshfield)	Asthma All	Asthma German	Extrinsic Asthma	HDM RAST +ve	HDM SPT +ve	Severe Asthma	Early Onset	Winter-Type	Summer-Type	Ln(IgE) continuous	Ln(IgE) categorical
D1S478	0.8404	1	48.53	0.03	0.03	0.04	0.5	0.9	0.12	0.3	0.13	0.8	0.002	0.0011
D1S234	0.8559	1	55.1	0.07	0.08	0.04	0.3	0.9	0.12	0.2	0.2	0.8	0.0002	0.00009
D1S255	0.7710	1	65.47	0.005	0.04	0.0015	0.04	0.4	0.03	0.15	0.7	0.2	0.002	0.005
D1S197	0.8285	1	76.27	0.007	0.06	0.002	0.12	0.4	0.09	0.07	0.5	0.11	0.08	0.2
D1S484	0.8050	1	169.68	0.08	0.12	0.012	0.004	0.003	0.3	0.3	0.08	0.3	0.007	0.013
D1S431	0.9008	1	182.35	0.12	0.13	0.02	0.03	0.04	0.5	0.3	0.3	0.2	0.005	0.005
D1S2815	0.9201	1	188.85	0.06	0.09	0.012	0.06	0.07	0.3	0.3	0.2	0.03	0.0008	0.0007
D1S238	0.8722	1	202.73	0.4	0.7	0.4	0.2	0.1	0.3	0.8	0.2	0.6	0.004	0.003
D1S2655	0.8976	1	216.82	0.7	0.9	0.6	0.2	0.2	0.2	0.9	0.7	0.7	0.05	0.007
D2S2374	0.9039	2	54.96	0.03	0.07	0.04	0.011	0.008	0.04	0.02	0.8	0.4	0.3	0.5
D2S2328	0.9545	2	61	0.02	0.04	0.014	0.007	0.007	0.008	0.04	0.8	0.06	0.14	0.4
D2S2294	0.9617	2	64.84	0.02	0.03	0.02	0.003	0.02	0.003	0.5	0.8	0.02	0.13	0.4
D2S2298	0.9585	2	65.94	0.02	0.02	0.02	0.003	0.02	0.002	0.06	0.8	0.014	0.11	0.3
D2S2113	0.9331	2	88.15	0.3	0.5	0.3	0.2	0.4	0.008	0.13	0.7	0.3	0.5	0.5
D3S1597	0.8199	3	29.92	0.7	0.7	0.4	0.6	0.9	0.4	0.4	0.6	0.8	0.009	0.006
D3S1286	0.9021	3	41.56	0.4	0.3	0.3	0.2	0.3	0.13	0.2	1	0.4	0.02	0.007
D3S1300	0.8748	3	80.32	0.12	0.3	0.2	0.09	0.0014	0.3	0.5	0.3	0.8	0.4	0.09
D3S1285	0.7673	3	91.18	0.07	0.08	0.2	0.07	0.0008	0.2	0.2	0.13	0.6	0.5	0.5
D4S1607	0.8843	4	183.63	0.3	0.3	0.3	0.07	0.05	0.2	0.005	0.07	0.6	0.4	0.3
D4S1535	0.8938	4	195.06	0.05	0.07	0.013	0.009	0.03	0.03	0.006	0.007	0.11	0.07	0.09
D4S2924	0.8934	4	199.93	0.06	0.09	0.007	0.002	0.03	0.02	0.009	0.02	0.2	0.08	0.15
D5S426	0.8990	5	51.99	0.006	0.006	0.03	0.008	0.14	0.04	0.002	0.007	0.2	0.09	0.4
D5S418	0.9101	5	58.55	0.015	0.03	0.06	0.004	0.2	0.012	0.007	0.012	0.4	0.02	0.07
D7S484	0.9204	7	53.5	0.5	0.7	0.2	0.4	0.5	0.5	0.4	0.5	0.9	0.02	0.009
D7S528	0.9481	7	57.79	0.2	0.4	0.014	0.14	0.3	0.3	0.5	0.5	0.6	0.0012	0.0007
D7S510	0.9783	7	59.93	0.14	0.4	0.02	0.3	0.3	0.2	0.6	0.6	0.4	0.0009	0.0013
D7S485	0.9688	7	60.68	0.1	0.3	0.01	0.3	0.3	0.13	0.6	0.7	0.4	0.0007	0.0004
D7S2548	0.9596	7	62.28	0.2	0.4	0.05	0.4	0.5	0.12	0.7	0.7	0.3	0.003	0.002
D7S691	0.9403	7	63.67	0.08	0.2	0.02	0.4	0.5	0.08	0.6	0.6	0.3	0.003	0.007
D7S2506	0.9313	7	69.56	0.2	0.4	0.13	0.9	0.8	0.14	0.7	0.7	0.3	0.007	0.011
D7S663	0.9049	7	78.65	0.06	0.05	0.08	0.3	0.4	0.2	0.5	0.3	0.14	0.0007	0.001
D7S669	0.8351	7	90.42	0.08	0.05	0.04	0.4	0.2	0.13	0.5	0.5	0.02	0.0014	0.0012
D9S257	0.9630	9	91.87	0.09	0.06	0.3	0.3	0.4	0.4	0.4	0.4	0.004	0.5	0.5
D9S283	0.9681	9	94.85	0.015	0.01	0.1	0.2	0.3	0.2	0.11	0.1	0.002	0.2	0.3
D9S1796	0.9745	9	97.53	0.02	0.014	0.07	0.3	0.2	0.05	0.07	0.14	0.006	0.07	0.13
D9S1781	0.9565	9	99.4	0.015	0.007	0.05	0.14	0.2	0.11	0.03	0.03	0.003	0.07	0.15
D9S1851	0.9708	9	103.42	0.02	0.008	0.04	0.06	0.2	0.2	0.05	0.02	0.003	0.3	0.5
D9S1786	0.9825	9	104.48	0.013	0.006	0.03	0.04	0.11	0.13	0.05	0.02	0.002	0.4	0.5
D9S176	0.9798	9	105.02	0.02	0.009	0.05	0.09	0.1	0.2	0.14	0.03	0.005	0.5	0.5
D9S1690	0.9709	9	106.63	0.06	0.04	0.2	0.2	0.14	0.4	0.4	0.13	0.007	0.5	0.5
D9S1784	0.9667	9	111.99	0.11	0.04	0.2	0.07	0.2	0.3	0.6	0.4	0.008	0.5	0.5
D10S547	0.8313	10	29.15	0.14	0.2	0.4	0.8	0.8	0.6	0.3	0.2	0.9	0.007	0.005
D10S191	0.8726	10	37.9	0.4	0.5	0.2	0.3	0.5	0.8	0.5	0.3	0.8	0.008	0.012
D11S922	0.9045	11	2.11	0.2	0.4	0.4	0.3	0.02	0.13	0.3	0.9	0.06	0.0005	0.0006
D11S902	0.8133	11	21.47	0.3	0.3	0.5	0.9	0.3	0.3	0.5	0.6	0.5	0.006	0.003
D11S935	0.7997	11	45.94	0.5	0.4	0.4	0.4	0.4	0.4	0.6	0.9	0.05	0.003	0.04
D11S968	0.8094	11	147.77	0.003	0.007	0.05	0.11	0.3	0.04	0.12	0.6	0.2	0.0005	0.0002
D12S355	0.8343	12	74.58	0.07	0.08	0.06	0.003	0.04	0.4	0.2	0.012	0.6	0.3	0.4
D12S1684	0.9339	12	86.4	0.02	0.015	0.05	0.002	0.05	0.9	0.15	0.2	0.4	0.08	0.4
D12S1667	0.9727	12	92.89	0.05	0.08	0.2	0.003	0.04	0.8	0.15	0.08	0.4	0.03	0.2
D12S81	0.9707	12	94.44	0.08	0.12	0.2	0.005	0.02	0.8	0.3	0.09	0.3	0.013	0.2
D12S351	0.9822	12	95.56	0.02	0.013	0.05	0.002	0.0003	0.5	0.3	0.05	0.3	0.0009	0.02
D12S95	0.9785	12	96.09	0.012	0.007	0.04	0.002	0.0002	0.5	0.2	0.06	0.4	0.0012	0.02
D12S327	0.9757	12	97.78	0.02	0.008	0.07	0.008	0.0009	0.4	0.05	0.13	0.2	0.04	0.2
D12S1716	0.9590	12	101.45	0.04	0.005	0.2	0.02	0.006	0.4	0.06	0.2	0.2	0.011	0.06
D12S1706	0.9696	12	104.12	0.12	0.015	0.3	0.07	0.06	0.6	0.3	0.4	0.2	0.007	0.2

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