Table 3 Rate of loss of Function Univariate Coefficients (ml per year) (after allowance for regression to the mean)
From: The Darlington and Northallerton Long Term Asthma Study: pulmonary function
Actual FEV1 | Best FEV1 | Best FVC | |||||
|---|---|---|---|---|---|---|---|
Estimate | 95% CI | Estimate | 95% CI | Estimate | 95% CI | ||
Gender (male v female) | 7.7 | 0.8+,16.1 | 6.2 | 2.5+,14.9 | 12.2 | 2.5,21.9 | |
Age at entry (per decade) (difference from age 50) | Linear | 5.6+ | 11.4+,0.2 | 10.1 + | 15.9 +,4.8 + | 2.1+ | 8.7+,4.5 |
quadratic | 4.3 + | 6.0 +,2.5 + | 5.0 + | 6.8 +,3.3 + | 4.5 + | 6.5 +,2.6 + | |
cubic | 1.3 | 0.3,2.3 | 2.0 | 1.0,2.9 | 1.4 | 0.3,2.6 | |
Duration of asthma at entry (per decade) (difference from duration 20 yrs) | Linear | 3.1+ | 7.4+,1.1 | 0.5 | 3.8+,4.8 | 0.1 | 4.8+,5.0 |
quadratic | 3.6 | 0.6,6.6 | 2.7 | 0.5+,5.8 | 5.6 | 2.2,9.0 | |
cubic | 0.9 + | 1.6 +,0.1 + | 0.9 + | 1.7 +,0.1 + | 1.4 + | 2.3 +,0.6 + | |
Atopic | 5.7+ | 14.2+,2.8 | 0.2 | 8.5+,8.9 | 3.0+ | 12.7+,6.7 | |
Childhood asthma (versus no childhood asthma) | Gap | 3.4+ | 16.7+,9.9 | 1.4 | 12.2+,15.0 | 4.0+ | 19.4+,11.3 |
Yes | 20.8 + | 30.6 +,10.9 + | 10.6 + | 20.9 +,0.4 + | 22.0 + | 33.3 +,10.6 + | |
Social Class (versus classes 1 and 2) | Three | 6.3+ | 16.5+,3.8 | 11.2 + | 21.7 +,0.8 + | 9.2+ | 20.8+,2.3 |
Four and Five | 10.2+ | 21.0+,0.7 | 14.5 + | 25.6 +,8.3 + | 8.6+ | 21.0+,3.9 | |
Amount smoked (per 10 pack years) | 1.5 | 0.6+,3.7 | 0.2 | 2.1+,2.4 | 2.9 | 0.4,5.4 | |
Best PEF(per 10% deficit) | 3.3 + | 5.3 +,1.2 + | 2.8 + | 4.8 +,0.7 + | 0.4+ | 2.7+,2.0 | |
Actual/Best PEF(10% deficit) | 12.7 + | 15.6 +,9.8 + | 2.8+ | 6.2+,0.6 | 0.6+ | 4.1+,2.8 | |