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Table 6 Multivariate Coefficients for Rate of loss of best FVC (after allowance for regression to the mean)

From: The Darlington and Northallerton Long Term Asthma Study: pulmonary function

   Age Excluded Age Included
   Coefficient (sd) p Coefficient (sd) p
Gender (male v female) 10.8 (5.6) 0.05 11.4 (5.6) 0.04
Asthma since childhood 16.0 + (6.0) 0.007 4.7+ (6.9) 0.49
Social Classes 1 & 2 (v. classes 4 & 5) 10.7 (6.4) 0.13 7.5 (6.4) 0.29
Social Class 3 (v. classes 4 & 5) 0.2+ (6.0)   1.4+ (5.9)  
Amount smoked (per 10 pack years) 1.9 (1.4) 0.18 0.9 (1.4) 0.52
Best PEF(per 10% deficit) 0.6+ (1,.4) 0.65 0.6+ (1.9) 0.67
Actual/Best PEF(10% deficit) 1.3 (1.8) 0.47 0.1 (1.9) 0.94
Age at entry (per decade) (difference from age 50) Linear    2.1+ (3.7)  
  quadratic    4.0+ (1.0)  
  cubic    1.4 (0.6) 0.02
Duration of asthma at entry (per decade) (difference from duration 20 yrs) Linear 4.0 (2.8)   0.8 (2.8)  
  quadratic 5.2 (1.7)   3.2 (1.8)  
  cubic 1.46 + (0.44) 0.001 0.97 + (0.46) 0.03
  1. (+) Indicates relative gain in function