Table 1 Case Data Summaries
Pt. No | Sex, Age (Years) | NTM Species | Radiographic Pattern | Duration of therapy prior to starting amikacin (months) | Amikacin Therapeutic Regimen | Duration of Inhaled Amikacin (months) | Current Therapeutic Regimen | Current Patient Status | Current Sputum Culture Status |
|---|---|---|---|---|---|---|---|---|---|
1 | F, 73 | MAC | nodular infiltrates, bronchiectasis in RUL, RML, lingula | 96 | CLA, RIF, EMB, inhaled amikacin | 9 | no oral antibiotics since 7/05; no inhaled amikacin since 6/06. | rare cough, wt loss, sweats, fatigue; abdominal cramps | negative for 21 months; now positive (MAC) |
2 | F, 67 | MAC | bilateral bronchiectasis, cavitary lesion RUL and bilateral apical fibrosis/scarring | 12 | AZI, RIF, EMB, inhaled amikacin | 4 | n/a | progressive disease; died | persistent positive at death |
3 | F, 66 | MAC, M. chelonae | bronchiectasis RML, RLL, LLL, lingula; bilateral apical fibrosis/scarring, centrilobular nodules | 48 | AZI, RIF, EMB, inhaled amikacin | 52 | AZI 500 mg/d since 4/06 | status post multiple lobectomies; cough and exertional dyspnea; daily low grade fevers | negative for 6 months., now positive; M. chelonae (resistant to amikacin |
4 | F, 71 | MAC | bronchiectasis and centrilobular nodules in posterior segments of both upper lobes, RML, lingula and lower lobes | 36 | CLA, inhaled amikacin | 16 | no antibiotics since 11/05 | rare cough | negative for 7 months; now positive; MAC (resistant to EMB, RIF) |
5 | F, 52 | MAC, M. chelonae | LUL wedge resection for MAC; bronchiectasis in LLL, RUL; R apical scarring, nodules in LLL, LUL, lingula | 0.5 | AZI, inhaled amikacin (thrombocytopenia on RIF/EMB) | 13 | inhaled amikacin 1000 mg/d and AZI 250 mg/d since 5/05 | improved with some cough, no purulence | negative for 6 mo. |
6 | F, 54 | MAC | bronchiectasis w/bronchial wall thickening RLL, RUL. | 13 | AZI, inhaled amikacin | 8 | AZI 500 mg 2/wk, inhaled amikacin 1000 mg 3/wk | rare cough, clinically well | no cough sputum (despite sputum induction) |