Skip to main content

Table 1 Demographic and clinical characteristics of 63 individuals recruited classified in 3 groups.

From: Exhaled and arterial levels of endothelin-1 are increased and correlate with pulmonary systolic pressure in COPD with pulmonary hypertension

 

Group ofCOPD+PAH (n = 12)

Group of COPD (n = 36)

Group of HS (n = 15)

Sex, M/F

11/1

32/4

9/6

Age, Years

70.8 (6.7)

67.6 (9.2)

58 (9.2)

Smoking, pack-years

27 (7)

25 (6)

0

FEV1%

39.35 (11.45)

48.13 (18.04)

98.05 (11.65)

FVC%

64.89 (14.90)

69.39 (19.1)

95.07 (13.34)

FEV1/FVC %

46.95 (6.81)

54.27 (12.46)

101.37 (8.5)

RV%

151 (38)

143 (32)

108 (11)

PaO2 (mmHg)

60.83 (4.76)

64.58 (6.16)

97.2 (0.7)

PaCO2 (mmHg)

39.4 (4.27)

41.78 (5.01)

38.4 (1.5)

PaPs (mmHg)

51.08 (12.2)*

26.05 (3.39)

NA

ET-1 EBC (pg/ml)

22.36 (4)

7.25 (0.23)

5.24 (0.47)

ET-1 art (pg/ml)

12.41 (2.13)

7.22 (0.21)

0.84 (0.37)

ET-1 ven (pg/ml)

14.53 (2.76)

7.29 (0.16)

1 (0.42)

FENO (ppb)

22.92 (11.38)

35.07 (17.53)

20.56 (3.67)

6MWD

383 (34)§

NA

NA

  1. Pulmonary function, arterial blood gases, pulmonary-artery systolic pressure, exhaled breath condensate counts and circulating levels are expressed in table 1. Statistical significant difference was found between groups 1 and 2 in pulmonary-artery systolic pressure, PaPs (p < 0.0001).
  2. Definition of abbreviations
  3. EBC: Exhaled Breath Condensate, ET-1: Endothelin-1, FENO: Exhaled Nitric Oxide, FEV1: Forced Expiratory Volume in the first second, FVC: Forced Vital Capacity, HS: Healthy Subjects, NO: Nitric Oxide, PAH: Pulmonary Artery Hypertension, RV: Residual Volume, PaPs: Pulmonary-artery systolic pressure, 6MWD: 6-minutes walking distance
  4. Data are presented as mean (± SD)
  5. NA = not applicable
  6. § n = 6 patients
  7. * Significant difference compared to COPD group: p < 0.001