| |
Group ofCOPD+PAH (n = 12)
|
Group of COPD (n = 36)
|
Group of HS (n = 15)
|
|---|
|
Sex, M/F
|
11/1
|
32/4
|
9/6
|
|
Age, Years
|
70.8 (6.7)
|
67.6 (9.2)
|
58 (9.2)
|
|
Smoking, pack-years
|
27 (7)
|
25 (6)
|
0
|
|
FEV1%
|
39.35 (11.45)
|
48.13 (18.04)
|
98.05 (11.65)
|
|
FVC%
|
64.89 (14.90)
|
69.39 (19.1)
|
95.07 (13.34)
|
|
FEV1/FVC %
|
46.95 (6.81)
|
54.27 (12.46)
|
101.37 (8.5)
|
|
RV%
|
151 (38)
|
143 (32)
|
108 (11)
|
|
PaO2 (mmHg)
|
60.83 (4.76)
|
64.58 (6.16)
|
97.2 (0.7)
|
|
PaCO2 (mmHg)
|
39.4 (4.27)
|
41.78 (5.01)
|
38.4 (1.5)
|
|
PaPs (mmHg)
|
51.08 (12.2)*
|
26.05 (3.39)
|
NA
|
|
ET-1 EBC (pg/ml)
|
22.36 (4)
|
7.25 (0.23)
|
5.24 (0.47)
|
|
ET-1 art (pg/ml)
|
12.41 (2.13)
|
7.22 (0.21)
|
0.84 (0.37)
|
|
ET-1 ven (pg/ml)
|
14.53 (2.76)
|
7.29 (0.16)
|
1 (0.42)
|
|
FENO (ppb)
|
22.92 (11.38)
|
35.07 (17.53)
|
20.56 (3.67)
|
|
6MWD
|
383 (34)§
|
NA
|
NA
|
- Pulmonary function, arterial blood gases, pulmonary-artery systolic pressure, exhaled breath condensate counts and circulating levels are expressed in table 1. Statistical significant difference was found between groups 1 and 2 in pulmonary-artery systolic pressure, PaPs (p < 0.0001).
-
Definition of abbreviations
- EBC: Exhaled Breath Condensate, ET-1: Endothelin-1, FENO: Exhaled Nitric Oxide, FEV1: Forced Expiratory Volume in the first second, FVC: Forced Vital Capacity, HS: Healthy Subjects, NO: Nitric Oxide, PAH: Pulmonary Artery Hypertension, RV: Residual Volume, PaPs: Pulmonary-artery systolic pressure, 6MWD: 6-minutes walking distance
- Data are presented as mean (± SD)
- NA = not applicable
- § n = 6 patients
- * Significant difference compared to COPD group: p < 0.001
