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Table 1 Number of animals with histological changes in the lung subsequent to the inhalations

From: Tolerability of inhaled N-chlorotaurine in the pig model

  NaCl
(n = 7)
1% NCT
(n = 7)
5% NCT
(n = 6)
1% NCT + 1% NH4Cl
(n = 6)
HE     
Infiltration with 4 1 3 2
   Neutrophilic granulocytes 4 5 5 3
   Eosinophilic granulocytes 2 2 1 0
   Lymphocytes 4 6 5 3
   Erythrocytes 3 5 2 3
Atelectasis 3 2 1 3
Bronchiolitis 3 2 4 4
Bronchitis 6 2 * 2 4
Lymphangiectasia 1 2 1 1
Capillary congestion 1 2 1 2
PAS     
Goblet cells increased 4 5 2 2
Increased production of mucus 4 5 2 3
Detached epithelial cells 0 0 2 0
Epithelial changes 0 0 1 0
Elastica     
Fragmentation of lamina elastica 3 1 2 3
Fragmentation of lamina externa 1 0 0 0
Reticulin     
Fibers collapsed 4 3 3 1
Thinned alveolar septa 3 2 2 3
Thickened alveolar septa 3 1 1 0
Emphysema 3 4 2 2
Bullae 1 2 1 2
Thickened pleura 1 0 0 0
  1. * P = 0.051 versus control
  2. † P = 0.08 versus control
  3. ‡ P = 0.065 versus control
  4. P > 0.1 for all other frequencies versus control