Table 1 Number of animals with histological changes in the lung subsequent to the inhalations
From: Tolerability of inhaled N-chlorotaurine in the pig model
NaCl (n = 7) | 1% NCT (n = 7) | 5% NCT (n = 6) | 1% NCT + 1% NH4Cl (n = 6) | |
|---|---|---|---|---|
HE | ||||
Infiltration with | 4 | 1 | 3 | 2 |
Neutrophilic granulocytes | 4 | 5 | 5 | 3 |
Eosinophilic granulocytes | 2 | 2 | 1 | 0 |
Lymphocytes | 4 | 6 | 5 | 3 |
Erythrocytes | 3 | 5 | 2 | 3 |
Atelectasis | 3 | 2 | 1 | 3 |
Bronchiolitis | 3 | 2 | 4 | 4 |
Bronchitis | 6 | 2 * | 2† | 4 |
Lymphangiectasia | 1 | 2 | 1 | 1 |
Capillary congestion | 1 | 2 | 1 | 2 |
PAS | ||||
Goblet cells increased | 4 | 5 | 2 | 2 |
Increased production of mucus | 4 | 5 | 2 | 3 |
Detached epithelial cells | 0 | 0 | 2‡ | 0 |
Epithelial changes | 0 | 0 | 1 | 0 |
Elastica | ||||
Fragmentation of lamina elastica | 3 | 1 | 2 | 3 |
Fragmentation of lamina externa | 1 | 0 | 0 | 0 |
Reticulin | ||||
Fibers collapsed | 4 | 3 | 3 | 1 |
Thinned alveolar septa | 3 | 2 | 2 | 3 |
Thickened alveolar septa | 3 | 1 | 1 | 0 |
Emphysema | 3 | 4 | 2 | 2 |
Bullae | 1 | 2 | 1 | 2 |
Thickened pleura | 1 | 0 | 0 | 0 |