Figure 1

GGA-induced expression of heat shock protein 70 (HSP70) in the lungs. (A) Representative immunoblotting data for HSP70 and β-actin are shown from two similar and independent experiments. The lung tissues from 5 mice at each time were collected. (B) Quantitative results after normalization to the β-actin signal were summarized. Data shown represent the means ± SE. a; 0 hour, b; 8 hours, c; 24 hours, d; 48 hours, e; 48 hours, repeated administration of geranylgeranylacetone (GGA) at 24 hours after first administration. *Statistically significant difference (p < 0.05) in comparison with the quantitative value of HSP70 level in the lung from mice with vehicle at 0 hours. (C) Representative immunohistochemical staining of HSP70 in GGA-treated mice at 24 hours after GGA administration. Arrows indicate HSP70-positive cells. (× 400 magnification.)