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Table 2 Observed mean value ± standard error and mean values of the % predicted ± standard error for the pulmonary function test variables for sex, smoking status and TLR4 Asp299Gly

From: Association of the TLR4 Asp299Gly polymorphism with lung function in relation to body mass index

 

Sex

Smoking Status#

TLR4 299#

 

Male (n = 754)

Female (n = 971)

Never Smoker

(n = 937)

Ever Smoker

(n = 788)

Wild type (n = 1490)

Polymorphic

(n = 235)

Observed FEV 1 (L)

3.78 ± 0.03

2.65 ± 0.02

3.21 ± 0.03

3.18 ± 0.03

3.18 ± 0.02

3.31 ± 0.06+

   % predicted

98.44 ± 0.59

102.86 ± 0.54

102.47 ± 0.53

99.09 ± 0.60&

100.91 ± 0.43

101.01 ± 1.05

Observed FVC (L)

4.73 ± 0.04

3.39 ± 0.02

3.97 ± 0.04

3.98 ± 0.04

3.95 ± 0.03

4.14 ± 0.07+

   % predicted

98.55 ± 0.55

103.24 ± 0.51

102.38 ± 0.50

99.77 ± 0.57&

101.10 ± 0.41

101.76 ± 0.97

Observed FEV 1 /FVC

0.80 ± 0.002

0.81 ± 0.002

0.81 ± 0.0.002

0.80 ± 0.0.002&

0.80 ± 0.002

0.80 ± 0.004

   % predicted

99.96 ± 0.29

100.06 ± 0.25

100.39 ± 0.26

99.57 ± 0.27&

100.11 ± 0.20

99.44 ± 0.49

Observed FEF 25-75 (L/s)

3.82 ± 0.05

2.89 ± 0.03

3.36 ± 0.04

3.21 ± 0.04&

3.28 ± 0.03

3.37 ± 0.08

   % predicted

101.28 ± 1.10

103.89 ± 1.06

105.64 ± 1.04

99.30 ± 1.13&

102.89 ± 0.82

101.80 ± 2.17

  1. Note: Predicted values are adjusted for age and height.
  2. * Comparison made between Male and Female p value < 0.05
  3. ** Comparison made between Male and Female p value < 0.10
  4. + Comparison made between wild type and polymorphic group p value < 0.05
  5. &Comparison made between never smoker and ever smoker group p value < 0.05
  6. # Separate prediction equations used for males and females.