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Table 3 Hazard ratios for 10-year all-cause mortality in 3 different models *

From: Low oxygen saturation and mortality in an adult cohort: the Tromsø study

 

Model 1

Model 2

Model 3

 

HR

(95% CI)

p-value

HR

(95% CI)

p-value

HR

(95% CI)

p-value

Age (years)

   

1.13

(1.12–1.14)

<0.001

1.12

(1.11–1.14)

<0.001

Sex

         

  Female

    

1

(reference)

 

1

(reference)

  Male

   

1.70

(1.49–1.95)

<0.001

1.66

(1.44–1.91)

<0.001

Self-reported diseases

         

  CVD

1.34

(1.17–1.54)

<0.001

1.18

(1.01–1.37)

0.033

1.18

(1.01–1.37)

0.035

  Asthma

1.33

(1.10–1.59)

0.003

1.03

(0.84–1.25)

0.81

0.92

(0.74–1.13)

0.41

  COPD

1.75

(1.42–2.16)

<0.001

1.29

(1.02–1.64)

0.036

1.13

(0.88–1.44)

0.35

  Diabetes

2.08

(1.67–2.59)

<0.001

2.09

(1.66–2.63)

<0.001

1.88

(1.48–2.40)

<0.001

  Hypertension

1.20

(1.05–1.36)

0.006

1.24

(1.08–1.43)

0.003

1.24

(1.07–1.43)

0.004

Smoking history

         

  Never

1

(reference)

 

1

(reference)

 

1

(reference)

 

  Former

1.29

(1.10–1.52)

0.002

1.24

(1.05–1.46)

0.010

1.16

(0.98–1.38)

0.082

  Current

2.11

(1.78–2.49)

<0.001

1.89

(1.58–2.26)

<0.001

1.68

(1.39–2.03)

<0.001

Self-reported symptoms

         

Dyspnoea€

         

  0

1

(reference)

 

1

(reference)

 

1

(reference)

 

  1

1.19

(1.05–1.36)

0.007

1.06

(0.92–1.22)

0.42

1.02

(0.89–1.18)

0.76

  ≥2

1.71

(1.40–2.08)

<0.001

1.32

(1.06–1.64)

0.015

1.15

(0.92–1.46)

0.23

Chronic cough with sputum

         

  Yes

1.71

(1.42–2.07)

<0.001

1.28

(1.04–1.57)

0.018

1.25

(1.01–1.54)

0.042

BMI (kg/m2)

         

  <18.5

2.08

(1.35–3.20)

0.001

1.99

(1.27–3.11)

0.003

1.76

(1.08–2.84)

0.022

  18.5–24.9

1

(reference)

 

1

(reference)

 

1

(reference)

 

  25.0–29.9

0.85

(0.74–0.97)

0.018

0.82

(0.71–0.95)

0.008

0.84

(0.73–0.98)

0.024

  ≥30.0

0.80

(0.68–0.96)

0.015

0.68

(0.56–0.82)

<0.001

0.71

(0.58–0.87)

0.001

CRP (mg/L)

         

  <5

1

(reference)

 

1

(reference)

 

1

(reference)

 

  ≥5

1.57

(1.35–1.82)

<0.001

1.39

(1.19–1.63)

<0.001

1.36

(1.16–1.60)

<0.001

FEV1% predicted

         

  <50

3.07

(2.46–3.81)

<0.001

   

1.99

(1.51–2.61)

<0.001

  50–80

1.54

(1.35–1.76)

<0.001

   

1.29

(1.11–1.49)

0.001

  ≥80

1

(reference)

    

1

(reference)

 

FEV1/FVC%

         

  <0.7

1.69

(1.49–1.93)

<0.001

   

1.11

(0.95–1.31)

0.20

  ≥0.7

1

(reference)

    

1

(reference)

 

SpO2 (%)

         

  ≤92

1.99

(1.33–2.96)

0.001

1.73

(1.15–2.60)

0.008

1.42

(0.92–2.18)

0.11

  93–95

1.36

(1.15–1.60)

<0.001

1.27

(1.06–1.51)

0.009

1.13

(0.94–1.36)

0.19

  ≥96

1

(reference)

 

1

(reference)

 

1

(reference)

 
  1. *Adjusted for age and sex in Model 1 and for all listed variables in the other two models.
  2. €Dyspnoea: 0, no dyspnoea, 1, dyspnoea while walking rapidly on level ground or up a moderate slope, ≥2, dyspnoea while walking slowly on level ground, washing or dressing, or at rest.
  3. Definition of abbreviations: HR, hazard ratio; CI, confidence interval; CVD, cardiovascular disease; COPD, chronic obstructive pulmonary disease; BMI, body mass index; CRP, C-reactive protein; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; SpO2, arterial oxygen saturation as measured by pulse oximetry.
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BMC Pulmonary Medicine

ISSN: 1471-2466

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