Figure 6
From: Immune targeting of the pleural space by intercostal approach
Suppression of pleural space B cell function by neutralizing anti-mouse IgM antibody leads to reduced broncho-alveolar bacterial clearance. (A) Intra-pleural injection of neutralizing anti-mouse IgM antibody or IgG isotype control into wt mice and intra-tracheal (i.t.) Escherichia coli (5×106 CFU) airway infection with analysis after 9 hrs of infection. (B) Clinical score and body temperature. (C) Bacterial titre in the BAL. (n = 10; data are shown in means ± S.D.; *p < 0.05; **p < 0.01; ***p < 0.001).