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Table 4 Nested case-control study, minimal detectable differences of biomarkers under different hypothetical assumptions with 1:2 case-control matching

From: Objectives, design and enrollment results from the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study (INSPIRE)

Biomarkers

Mean (SD)*

20% RSV exposed: 83 asthma cases

30% RSV exposed: 166 asthma cases

Urine Leukotrienes

83.8 pg/mg (38.2)

14.4

10.2

KL-6

127.1 U/mL (69.1)

26.2

18.4

Urinary PGI

175 pg/mL (12.1)

4.6

3.2

  1. * Based on references [46-50].
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BMC Pulmonary Medicine

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