Figure 2
The location of TLR9 SNPs and TLR9 signaling pathway. (A) Schematic representation of human chromosome 3 showing location of TLR9 gene. (B) Schematic representation of the selected single nucleotide polymorphisms (SNPs) in TLR9. Drak regions in exon 1&2: protein coding region. (C) Schematic representation of selected SNPs in TLR9 protein. TLR9: Toll-Like Receptor; LRR: Leucine-rich repeat; TIR: Toll-Interleukin-1 Receptor Domain; LD: linkage disequilibrium. (D) The signaling pathway of TLR9. TLR9 homodimer could recruit adaptor proteins MyD88. MyD88 recruits IRAK-4 and activates NF-ĪŗB through IRAKs, TRAF6, TAK1, and IĪŗKs, resulting in cell apoptosis or inflammatory cytokine synthesis. TLR9: Toll-Like Receptor 9; MyD88: Myeloid Differentiation Primary Response Gene 88; NF-ĪŗB: nuclear factor kappa B; IRAK: Interleukin-1 Receptor associated kinase 1; TRAF 6: TNF Receptor Associated Factor 6; TAK1: TGF-b-Actiated Kinase 1; IĪŗK: IĪŗB kinase; IĪŗB: Inhibitor of NF-ĪŗB.