Figure 3

Variables from volumetric capnography between the group of patients with cystic fibrosis (CFG) (n=64) and the control group (CG) (n=64). Data are presented as the confidence interval of the median. Time points analyzed: (1) baseline (rest), (2) 1–2 min of activity, (3) 3–4 min of activity, (4) 5–6 min of activity, and (5) postexercise. α=0.01 by Bonferroni correction. The Mann–Whitney test (data not normally distributed) was used to compare the CFG and CG, and correlations between the time points in each group were determined using the Friedman test (non-parametric, repeated measures); in cases with a positive p-value, the Wilcoxon signed-rank test was performed. (A) Expired minute volume (VE). There was no difference between the CF and CFG for the different time points analyzed. In the cluster analysis, for the CFG, time point 1 differed from 2 to 5; time point 2 differed from 1, 4, and 5; time point 3 differed from 1 and 5; time point 4 differed from 1, 2, and 5; and time point 5 differed from 1 to 4 (p≤0.001). For the CG, time point 1 differed from 2 to 5; time point 2 differed from 1, 3, 4, and 5; time point 3 differed from 1, 2, and 5; and time point 5 differed from 1 to 4 (p≤0.001). (B) VCO₂. Higher values were observed in the CG than CFG (time point: (1) p=0.003; (2) p=0.005; (3) p=0.001; (4) p=0.002; (5) p≤0.001). In the cluster analysis, for the CFG, time point 1 differed from 2 to 5; time point 2 differed from 1, 3, 4, and 5; time point 3 differed from 1, 2, and 5; and time point 5 differed from 1 to 4 (p≤0.001). For the CG, time point 1 differed from 2 to 5; time point 2 differed from 1, 3, and 4; time points 3 and 4 differed from 1, 2, and 5; and time point 5 differs from 1, 3, and 4 (p≤0.001). (C) PetCO₂. Higher values were observed in the CG than CFG (time point 1, p = 0.002; other time points, p≤0.001). In the cluster analysis for the CFG, time point 1 differed from 2 to 4; time points 2 to 4 differed from 1 and 5; and time point 5 differed from 2 to 4 (p≤0.001). For the CG, time point 1 differed from 2 to 4; time point 2 differed from 1, 4, and 5; time point 3 differed from 1 and 5; time point 4 differed from 1, 2, and 5; and time point 5 differed from 2 to 4 (p≤0.001). (D) VD/VT. There was no difference between the CG and CFG for the different time points analyzed. In the cluster analysis for the CFG, time point 1 differed from 2 to 4; time point 2 differed from 1; time points 3 and 4 differed from 1 and 5; and time point 5 differed from 3 and 4 (p≤0.001). For the CG, time point 1 differed from 2 to 5; time point 2 differed from 1; time points 3 and 4 differed from 1 and 5; and time point 5 differed from 1, 3, and 4 (p≤0.001).