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Table 1 Clinical characteristics of cohort patients based on infection status

From: Clinical outcomes associated with Staphylococcus aureus and Pseudomonas aeruginosa airway infections in adult cystic fibrosis patients

 

No PA/SA

SA only

PA

P-value

n (%)

14 (16.7 %)

20 (24.1 %)

50 (59.5 %)

-

Age (years)

30.9 (±13.7)

28.5 (±12.2)

35.6 (±12.8)

0.097

Female sex (%)

8 (57.1 %)

9 (45.0 %)

25 (50.0 %)

-

Number of sputum samples

3.6 (±3.7)

3.3 (±2.5)

5.5 (±4.3)

0.055

Number of routine visits

6.6 (±5.3)

4.4 (±3.6)

7.9 (±6.9)

0.096

BMI

21.1 (±2.5)

22.5 (±3.5)

22.0 (±4.5)

0.608

FEV1 (% predicted)

70.9 (±21.0)

66.5 (±22.1)

56.3 (±27.2)

0.096

FVC (% predicted)

85.8 (±22.1)

82.8 (±19.3)

72.7 (±26.3)

0.110

Exacerbation rate

0.43

0.20

1.20

<0.02*

Hospitalization rate

0.21

0.15

1.30

<0.10

Total clinical score (out of 95)

71.1 (±14.1)

68.6 (±10.9)

60.8 (±14.6)

0.017a

Clinical subscore (out of 45)

35.3 (±4.6)

35.1 (±3.3)

33.0 (±3.8)

0.048*

Radiographic subscore (out of 25)

18.9 (±4.0)

17.7 (±2.9)

15.9 (±2.7)

0.003a

Pulmonary function subscore (out of 25)

18.5 (±5.1)

18.0 (±5.1)

15.3 (±6.2)

0.081

Complication subscore (out of 37)

1.5 (±2.3)

2.3 (±2.6)

3.4 (±4.2)

0.185

CRP

2.50 (±3.5)

4.8 (±3.2)

10.6 (±10.0)

0.005a,b

  1. SA = Staphylococcus aureus; PA = Pseudomonas aeruginosa; SD = standard deviation; BMI = body mass index; FEV1 = forced expiratory volume in 1 s; FVC = forced vital capacity; CRP = C-reactive protein
  2. Data are expressed as mean (± SD) or number (% total), except for the exacerbation and hospitalization rates expressed as mean rates calculated by Poisson regression
  3. P-values were determined using the ANOVA or Chi-squared test. For exacerbation rate and hospitalization rate, P-values were determined by a comparison with a null model
  4. Comparisons between groups were done using Tukey’s test. Tukey’s test reported the following differences: ap < 0.05, “No PA/SA” vs. “PA”
  5. bp < 0.05, “SA only” vs. “PA”
  6. CRP data was only available in a subset of patients and results in Table 2 were collected from the different groups are as follows: Group No PA/SA: 11/14; Group SA only: 16/20; Group PA: 35/50