Table 3 Distributions of genotypes of IL-17 and their associations with risk of CWP
From: Polymorphisms in interleukin 17A gene and coal workers’ pneumoconiosis risk in a Chinese population
Variables | CWP cases | Controls | P a | OR (95 % CI) | P b | OR (95 % CI)b | ||
|---|---|---|---|---|---|---|---|---|
Number | Percent | Number | Percent | |||||
rs2275913 | n =692 | n = 687 | ||||||
GG | 221 | 31.9 | 225 | 32.8 | 1.00 | 1.00 | ||
AG | 333 | 48.1 | 326 | 47.5 | 0.749 | 1.04 (0.82-1.32) | 0.665 | 1.05 (0.83-1.34) |
AA | 138 | 19.9 | 136 | 19.8 | 0.832 | 1.03 (0.76-1.40) | 0.734 | 1.05 (0.78-1.43) |
G allele | 775 | 56.0 | 776 | 56.5 | 1.00 | 1.00 | ||
A allele | 609 | 44.0 | 598 | 43.5 | 0.800 | 1.02 (0.88-1.19) | 0.695 | 1.03 (0.89-1.20) |
ADD | 0.802 | 1.02 (0.88-1.18) | 0.699 | 1.03 (0.88-1.20) | ||||
DOM | 0.746 | 1.03 (0.83-1.30) | 0.647 | 1.05 (0.84-1.32) | ||||
REC | 0.946 | 1.01 (0.77-1.32) | 0.880 | 1.02 (0.78-1.33) | ||||
rs3748067 | n = 693 | n = 690 | ||||||
GG | 486 | 70.1 | 460 | 66.7 | 1.00 | 1.00 | ||
GA | 193 | 27.8 | 199 | 28.8 | 0.476 | 0.92 (0.73-1.16) | 0.408 | 0.90 (0.71-1.15) |
AA | 14 | 2.0 | 31 | 4.5 | 0.010 | 0.43 (0.22-0.81) | 0.011 | 0.43 (0.23-0.83) |
G allele | 1165 | 84.1 | 1119 | 81.1 | 1.00 | 1.00 | ||
A allele | 221 | 15.9 | 261 | 18.9 | 0.040 | 0.81 (0.67-0.99) | 0.035 | 0.81 (0.66-0.99) |
ADD | 0.041 | 0.82 (0.67-0.99) | 0.036 | 0.81 (0.67-0.99) | ||||
DOM | 0.166 | 0.85 (0.68-1.07) | 0.139 | 0.84 (0.67-1.06) | ||||
REC | 0.012 | 0.44 (0.23-0.83) | 0.014 | 0.44 (0.23-0.85) | ||||
rs4711998 | n = 693 | n = 689 | ||||||
AA | 350 | 50.5 | 353 | 51.2 | 1.00 | 1.00 | ||
GA | 293 | 42.3 | 279 | 40.5 | 0.610 | 1.06 (0.85-1.31) | 0.558 | 1.06 (0.86-1.33) |
GG | 50 | 7.2 | 57 | 8.3 | 0.556 | 0.88 (0.59-1.33) | 0.628 | 0.90 (0.60-1.36) |
A allele | 993 | 71.6 | 985 | 71.5 | 1.00 | 1.00 | ||
G allele | 393 | 28.4 | 393 | 28.5 | 0.924 | 0.99 (0.84-1.17) | 0.984 | 1.00 (0.85-1.18) |
ADD | 0.923 | 0.99 (0.84-1.17) | 0.984 | 1.00 (0.85-1.18) | ||||
DOM | 0.787 | 1.03 (0.83-1.27) | 0.711 | 1.04 (0.84-1.29) | ||||
REC | 0.462 | 0.86 (0.58-1.28) | 0.518 | 0.88 (0.59-1.31) | ||||
rs8193036 | n = 693 | n = 690 | ||||||
CC | 347 | 50.1 | 311 | 45.1 | 1.00 | 1.00 | ||
TC | 292 | 42.1 | 298 | 43.2 | 0.252 | 0.88 (0.70-1.10) | 0.233 | 0.87 (0.70-1.09) |
TT | 54 | 7.8 | 81 | 11.7 | 0.007 | 0.60 (0.41-0.87) | 0.006 | 0.59 (0.40-0.86) |
C allele | 986 | 71.1 | 920 | 66.7 | 1.00 | |||
T allele | 400 | 28.9 | 460 | 33.3 | 0.011 | 0.81 (0.69-0.95) | 0.009 | 0.80 (0.68-0.95) |
ADD | 0.011 | 0.81(0.69-0.95) | 0.009 | 0.81 (0.69-0.95) | ||||
DOM | 0.062 | 0.82 (0.66-1.01) | 0.053 | 0.81 (0.66-1.00) | ||||
REC | 0.014 | 0.64 (0.44-0.91) | 0.011 | 0.63 (0.43-0.90) | ||||