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Table 1 Sensitivity, specificity, positive predictive value and negative predictive value of culture, microscopy and Xpert MTB/RIF performed on lavage specimens

From: The utility of Xpert MTB/RIF performed on bronchial washings obtained in patients with suspected pulmonary tuberculosis in a high prevalence setting

 

Smear Microscopy

Xpert MTB/RIF

Adjusted Xpert MTB/RIFa

%

95 % CI

%

95 % CI

%

95 % CI

Sensitivity

41.0

26 – 57.8

92.3

78 – 98

88.6

74.6 – 95.7

Specificity

98.6

91.6 – 99.9

87.7

77.4 – 93.9

91.2

81.1 – 96.4

PPV

94.1

69.2 – 99.7

80.0

64.9 – 89.9

86.7

72.5 – 94.4

NPV

75.8

65.7 – 83.7

95.5

86.6 – 98.8

92.5

82.7 – 97.2

  1. 95 % CI 95 % confidence interval, PPV positive predictive value, NPV negative predictive value
  2. aSecondary analysis (including cases diagnosed on clinical, histological and radiological means)