Serum B cell–activating factor (BAFF) level in connective tissue disease associated interstitial lung disease

BMC Pulmonary Medicine

Table 2 ROC analysis comparing serum BAFF, KL-6, and SP-D levels between patients with CTD-ILD and CFIP

	AUC	Cut-off value	Sensitivity, % (95 % CI)	Specificity, % (95 % CI)	Likelihood ratio
BAFF	0.823	1.7 ng · mL⁻¹	67.6 (49.4 to 82.6)	94.7 (73.9 to 99.8)	12.85
KL-6	0.566	1562 U · mL⁻¹	79.4 (62.1 to 91.3)	52.6 (28.8 to 75.5)	1.67
SP-D	0.643	158 ng · mL⁻¹	47.1 (29.7 to 64.8)	77.7 (52.3 to 93.5)	2.11

BAFF: B cell–activating factor belonging to the tumour necrosis factor family; SP-D: surfactant protein D; KL-6: Krebs von den Lungen-6; CTD-ILD: interstitial lung disease associated with connective tissue disease; CFIP: chronic fibrosing interstitial lung disease; ROC: receiver operating characteristic; AUC: area under the ROC curve; CI: Confidence interval

ISSN: 1471-2466