Skip to main content

Table 2 Cases of chronic infection

From: An international, multicentre evaluation and description of Burkholderia pseudomallei infection in cystic fibrosis

Patient Duration of infection Year of acquisition Eradication attempted Eradication successful Outcome
1 (O’Carroll, 2003) [12] >15 years 1987 No N/A Slow decline in lung health consistent with CF; transplant 2004
10 (O’Carroll, 2003) [12] 11 years 2001 No N/A Slow decline in lung health consistent with CF
3 (Schülin, 2001) [14] >9 years 1992 Yes No Increased frequency of exacerbations
15 >8 years 2005 Yes No Accelerated decline; transplant declined due to B. pseudomallei infection; B. pseudomallei septicaemia;a died 2009
22 (Radhakrishna, 2014) [17] 7 years 2011 Yes Yes No obvious clinical impact
2 7 years Early 1990’s No N/A Spontaneously clearance of infection after approx. 7 years; 11 years later died of neutropenic sepsis complicating treatment of Duke’s C colon cancer.
7 (Holland, 2002) [16] >6 years 2000 Yes No Accelerated decline with increased frequency of exacerbations; B. pseudomallei septicaemia; died 2009
17 6 years 2007 No N/A Slow decline in lung health consistent with CF
18 6 years 2007 Yes No Accelerated decline; transplant declined due to B. pseudomallei; died 2013
11 (Holland, 2002) [15] 5 years 2001 Yes No Accelerated decline; transplant 2006; died 2011
23 >12 months 2012 Yes No Progressive destruction right upper lobe
6 (Holland, 2002) [16] >4 years 1999 Yes No After presumed latency of 4 years developed accelerated decline with pneumonia; died 2004
24 4 years 2009 Yes Unknown Fall in lung function; stable after targeted antimicrobial therapy
14 (Barth, 2007) [9] >2 years 2005 Yes No Accelerated decline with rapid decrease in lung function and recurrent exacerbations over 2 years; long term outcome unknown
8 (O’Carroll, 2003) [12] 2 years 2000 Yes No Rapid decline post infection; died 2 years after initial infection
21 2 years 2010 Yes No Accelerated decline; transplant 2012 with persistent infection post-transplant
12 (O’Carroll, 2003) [12] 2 years 2001 Yes Yes Repeated admissions with pneumonia, treated with 3 week courses of ceftazidime, meropenem, tobramycin; infection ultimately spontaneously cleared
4 (Visca, 2001) [15] 1 year 1998 Yes Yes Deteriorating pulmonary sepsis, increasingly refractory to anti-pseudomonal antibiotics; cleared infection with antimicrobial therapy; still alive 2013
13 (Asiah, 2006) [8] 1 year 2004 Yes Yes Increased pulmonary sepsis during infection with B. pseudomallei; remained well 5 months after completing targeted anti-microbial therapy
  1. aRecurrent episodes of B. pseudomallei bacteremia
  2. bIn patient 5 the duration of infection and long term outcome was unknown