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Table 3 The mean spirometric values and the mean serum concentrations of examined cytokines in patients with progressive and non-active sarcoidosis and in radiological stage I,II and III

From: Circulating concentration of markers of angiogenic activity in patients with sarcoidosis and idiopathic pulmonary fibrosis

  Progressive, active sarcoidosis n = 18 Non active sarcoidosis n = 25 Sarcoidosis Stage I n = 10 Sarcoidosis Stage II n = 20 Sarcoidosis Stage III n = 13
  (mean ± SEM) (mean ± SEM) (mean ± SEM) (mean ± SEM) (mean ± SEM)
  Median (Interquartile range) Median (Interquartile range) Median (Interquartile range) Median (Interquartile range) Median (Interquartile range)
Age (years) 35.1 ± 1.9 36.2 ± 1.7 30.3 ± 1.5 35.7 ± 1.9 40.3 ± 2.3
32.5 (30.0–40.0) 34.0 (29.0–40.0) 29.0 (29.0–30.8) 33.5 (30.5–39.0) 40.0 (33.5–44.3)
FEV1 (% of predicted) 87.1 ± 2.0 85.4 ± 2.4 87.7 ± 2.7 87.2 ± 1.8 83.1 ± 4.3
84.0 (81.0–92.0) 87.0 (80.0–94.0 90.0 (82.8–101.0) 85.0 (80.5–97.3) 85.0 (81.0–91.5)
FVC (% of predicted) 96.8 ± 3.4 95.9 ± 2.7 100.2 ± 3.7 97.6 ± 2.8 90.7 ± 4.6
95.0 (88.0–108.0) 98.0 (91.0–103.0) 100.0 (96.0–105.5) 100.0 (89.5–104.0) 90.0 (82.8–101.0)
FEV1%VC (%) 75.6 ± 1.8 75.7 ± 1.2 77.0 ± 1.8 74.8 ± 1.5 75.8 ± 2.2
74.5 (70.0–82.0) 75.5 (71.0–79.0) 77.0 (74.0–80.0) 74.0 (70.5–77.5) 75.0 (68.8–83.5)
Angiopoeitin-2 (pg/ml) 239.1 ± 37.9 208.4 ± 41.5 355.6 ± 66.0* 206.0 ± 37.9 142.2 ± 42.2
220.0 (120.1–380.6) 169.0 (69.9–281.5) 361.7 (170.0–518.8) 178.3 (98.6–310.0) 89.0 (13.5–192.9)
Folistatin (pg/ml) 372.9 ± 51.9 346,456 ± 41.1 448.5 ± 59.1 328.8 ± 46.4 331.9 ± 62.2
348.8 (258.6–466.7) 304.6 (206.1–444.0) 406.5 (265.1–636.5) 296.6 (211.7–416.8) 357.9 (154.5–472.3)
GM-CSF (pg/ml) 28.8 ± 8.0 33.7 ± 5.7 45.4 ± 12.9 32.4 ± 6.0 20.1 ± 6.9
12.8 (10.3–32.0) 32.1 (7.6–56.0) 33.4 (10.5–88.2) 24.2 (8.3–52.1) 12.7 (2.5–34.6)
IL-8 (pg/ml) 28.4 ± 7.7 32.4 ± 4.4 47.7 ± 11.8 29.0 ± 4.6 20.4 ± 4.7
14.5 (13.7–22.7) 39.2 (11.9–48.7) 42.8 (15.1–85.7) 18.4 (13.3–46.6) 12.8 (10.7–28.8)
PDGF-BB (pg/ml) 5304.0 ± 786.5 5689.8 ± 772.3 5865.1 ± 856.4 5564.5 ± 863.6 5213.5 ± 1123.2
4591.3 (3054.5–6419.3) 5547.9 (2724.6–7594.7) 5044.5 (3544.5–8742.6) 4757.8 (2655.4–7972.2) 4575.5 (1536.6–8612.5)
PECAM-1 (pg/ml) 2537.3 ± 330.4 2456.6 ± 327.9 3126.1 ± 328.6 2377.3 ± 394.0 2175.5 ± 389.7
2469.8 (1502.1–3418.4) 2190.3 (1295.8–2854.1) 2596.1 (2323.9–4164.1) 1926.5 (1262.9–2818.9) 2290.7 (862.3–3340.9)
VEGF (pg/ml) 93.9 ± 13.7 84.9 ± 8.6 116.8 ± 21.5 87.9 ± 9.4 68.29 ± 9.6
79.9 (60.6–117.8) 87.6 (53.5–101.2) 98.8 (61.5–165.9) 87.9 (60.4–100.3) 62.7 (34.3–100.4)
  1. *p < 0.05 sarcoidosis stage I vs sarcoidosis stage II and III