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Table 1 Baseline characteristics of COPDGene and Framingham Heart Study (FHS) participants with Interstitial Lung Abnormality (ILA) by identification method

From: A comparison of visual and quantitative methods to identify interstitial lung abnormalities

Variablea Number (%) or Median (standard deviation) where appropriate
Demographic parameters COPDGene FHS
ILA by Visual Assessment ILA by HAAsb ILA by Visual Assessment ILA by HAAsb
n = 194 (8 %) n = 26 (1 %) n = 177 (7 %) n = 46 (2 %)
Age (years) 64 (10) 62 (8) 70 (12) 65 (13)
Gender (female) 101 (52 %) 14 (54 %) 89 (50 %) 19 (41 %)
Race (African-American) 56 (29 %) 14 (54 %) - -
Body Mass Index 28 (7) 33 (4) 28 (5) 32 (5)
Pack years of smoking 44 (27) 42 (26) 26 (20) 18 (15)
Current Smoker 97 (50 %) 18 (69 %) 17 (10 %) 5(11 %)
Spirometric Parameters
FEV1 (% of predicted)d 81 % (21) 80 % (32) 98 % (17) 96 % (16)
FVC (% of predicted)d 88 % (17) 78 % (23) 101 % (15) 96 % (15)
FEV1/FVC %d 71 % (14) 81 % (18) 97 % (9) 100 % (7)
DLCO (% of predicted)e - - 86 % (14) 86 % (17)
Chest CT parameters
Total Lung Capacity (TLC)f 5.0 (1.4) 3.5 (1.4) 4.6 (1.2) 3.8 (0.9)
TLC % of predictedf 95 % (20) 57 % (17) 79 % (17) 64 % (14)
  1. aData missing in the COPDGene study (n = 2416) for COPD status and pulmonary function testing (n = 1, <1 %) and TLC (n = 19, <1 %). Data missing in the FHS (n = 2633) for spirometry (n = 165, 6 %), diffusion capacity of carbon monoxide (DLCO, n = 572, 22 %), and total lung capacity (n = 192, 7 %)
  2. bHAAs = High Attenuation Areas (defined by attenuation values between −600 and −250 Hounsfield Units [HUs]) [11]
  3. cGold Stage ≥ 2 includes those with an FEV1/FVC % ≥ 0.70, FEV1 < 80 % of predicted
  4. dPost-bronchodilator pulmonary function measurements presented. Predicted values for FEV1 and FVC are derived from Crapo et al. [34]
  5. eDLCO = Diffusion capacity of carbon monoxide, predicted values are derived from Miller et al. [27]
  6. fQuantitative metrics of TLC were performed using Airway Inspector (http://airwayinspector.acil-bwh.org). HU: Hounsfield units. Percent of predicted total lung capacity based on ATS/ERS guidelines [35]