Table 1 HSPA1L, HSPA1A and HSPA1B genotype and allele frequencies in IPF patients and healthy controls
IPF n = 168 | Control n = 205 | |||||||
|---|---|---|---|---|---|---|---|---|
Models | Allele/Genotypes | n | f | n | f | OR | Pc | 95 % C.I. |
HSPA1L (C/T rs2075800) | ||||||||
C | 181 | 0.79 | 230 | 0.56 | 1 | |||
T | 155 | 0.21 | 180 | 0.44 | 1.09 | 0.54 | 0.81–1.46 | |
C | CC | 53 | 0.31 | 59 | 0.28 | 1 | – | – |
CT | 75 | 0.44 | 112 | 0.54 | 0.74 | – | ||
TT | 40 | 0.23 | 34 | 0.16 | 1.30 | 0.10 | 0.72–2.35 | |
D | CC | 53 | 0.31 | 59 | 0.28 | 1 | – | – |
CT + TT | 115 | 0.68 | 146 | 0.71 | 0.87 | 0.56 | 0.56–1.36 | |
R | CC + CT | 128 | 0.76 | 171 | 0.83 | 1 | – | – |
TT | 40 | 0.23 | 34 | 0.16 | 1.57 | 0.08 | 0.94–2.62 | |
HSPA1L (A/G rs2227956) | ||||||||
A | 331 | 0.99 | 389 | 0.95 | 1 | – | – | |
G | 5 | 0.01 | 21 | 0.05 | 0.27 | 0.01 | 0.10–0.75 | |
C | AA | 163 | 0.97 | 184 | 0.89 | 1 | – | – |
AG | 5 | 0.02 | 21 | 0.10 | 0.26 | 0.01 | 0.09–0.72 | |
GG | 0 | 0.00 | 0 | 0.00 | – | – | – | |
D | AA | 163 | 0.97 | 184 | 0.89 | 1 | – | – |
AG + GG | 5 | 0.02 | 21 | 0.10 | 0.26 | 0.01 | 0.09–0.72 | |
R | AA + AG | 168 | 1.00 | 205 | 1.00 | 1 | – | – |
GG | 0 | 0.00 | 0 | 0.00 | – | – | – | |
HSPA1A (G/C rs1043618) | ||||||||
G | 261 | 0.77 | 295 | 0.72 | 1 | – | – | |
C | 75 | 0.22 | 115 | 0.28 | 0.73 | 0.07 | 0.52–1.03 | |
C | GG | 100 | 0.59 | 102 | 0.49 | 1 | – | – |
GC | 61 | 0.36 | 91 | 0.44 | 0.68 | – | ||
CC | 7 | 0.04 | 12 | 0.05 | 0.59 | 0.16 | 0.22–1.57 | |
D | GG | 100 | 0.59 | 102 | 0.49 | 1 | – | – |
GC + CC | 68 | 0.40 | 103 | 0.50 | 0.68 | 0.07 | 0.45–1.03 | |
R | GG + GC | 161 | 0.95 | 193 | 0.94 | 1 | – | – |
CC | 7 | 0.04 | 12 | 0.05 | 0.69 | 0.46 | 0.26–1.81 | |
HSPA1B (G/A rs1061581) | ||||||||
G | 199 | 0.56 | 215 | 0.52 | 1 | – | – | |
A | 137 | 0.44 | 195 | 0.48 | 1.3 | 0.06 | 0.98–1.76 | |
C | GG | 41 | 0.24 | 48 | 0.23 | 1 | – | – |
GA | 117 | 0.69 | 119 | 0.58 | 1.15 | – | – | |
AA | 10 | 0.05 | 38 | 0.18 | 0.30 | 0.001 | 0.13–0.69 | |
D | GG | 41 | 0.24 | 48 | 0.23 | 1 | – | – |
GA + AA | 127 | 0.75 | 157 | 0.76 | 0.94 | 0.82 | 0.58–1.52 | |
R | GG + AG | 158 | 0.94 | 167 | 0.81 | 1 | – | – |
AA | 10 | 0.05 | 38 | 0.18 | 0.27 | 0.0003 | 0.13–0.57 | |