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Table 1 HSPA1L, HSPA1A and HSPA1B genotype and allele frequencies in IPF patients and healthy controls

From: Analysis of heat shock protein 70 gene polymorphisms Mexican patients with idiopathic pulmonary fibrosis

   IPF n = 168 Control n = 205    
Models Allele/Genotypes n f n f OR Pc 95 % C.I.
  HSPA1L (C/T rs2075800)        
  C 181 0.79 230 0.56 1   
  T 155 0.21 180 0.44 1.09 0.54 0.81–1.46
C CC 53 0.31 59 0.28 1
  CT 75 0.44 112 0.54 0.74  
  TT 40 0.23 34 0.16 1.30 0.10 0.72–2.35
D CC 53 0.31 59 0.28 1
  CT + TT 115 0.68 146 0.71 0.87 0.56 0.56–1.36
R CC + CT 128 0.76 171 0.83 1
  TT 40 0.23 34 0.16 1.57 0.08 0.94–2.62
  HSPA1L (A/G rs2227956)        
  A 331 0.99 389 0.95 1
  G 5 0.01 21 0.05 0.27 0.01 0.10–0.75
C AA 163 0.97 184 0.89 1
  AG 5 0.02 21 0.10 0.26 0.01 0.09–0.72
  GG 0 0.00 0 0.00
D AA 163 0.97 184 0.89 1
  AG + GG 5 0.02 21 0.10 0.26 0.01 0.09–0.72
R AA + AG 168 1.00 205 1.00 1
  GG 0 0.00 0 0.00
  HSPA1A (G/C rs1043618)        
  G 261 0.77 295 0.72 1
  C 75 0.22 115 0.28 0.73 0.07 0.52–1.03
C GG 100 0.59 102 0.49 1
  GC 61 0.36 91 0.44 0.68  
  CC 7 0.04 12 0.05 0.59 0.16 0.22–1.57
D GG 100 0.59 102 0.49 1
  GC + CC 68 0.40 103 0.50 0.68 0.07 0.45–1.03
R GG + GC 161 0.95 193 0.94 1
  CC 7 0.04 12 0.05 0.69 0.46 0.26–1.81
  HSPA1B (G/A rs1061581)        
  G 199 0.56 215 0.52 1
  A 137 0.44 195 0.48 1.3 0.06 0.98–1.76
C GG 41 0.24 48 0.23 1
  GA 117 0.69 119 0.58 1.15
  AA 10 0.05 38 0.18 0.30 0.001 0.13–0.69
D GG 41 0.24 48 0.23 1
  GA + AA 127 0.75 157 0.76 0.94 0.82 0.58–1.52
R GG + AG 158 0.94 167 0.81 1
  AA 10 0.05 38 0.18 0.27 0.0003 0.13–0.57
  1. C codominant, D dominant, R recessive, Pc p value corrected, IPF idiopathic pulmonary fibrosis, OR odds ratio, I.C. confidence interval. Significant associations are highlighted with bold type