Mortality and drug therapy in patients with chronic obstructive pulmonary disease: a network meta-analysis

BMC Pulmonary Medicine

Table 2 All-cause mortality (hazard ratios) of included studies

Trial	Treatment	Comparator	ITT				On treatment
Trial	Treatment	Comparator	HR	LCI	UCI	p value	HR	LCI	UCI	p value
TORCH	SFC	Placebo	0.811	0.670	0.982	0.030	NR	NR	NR	NR
	SFC	Salmeterol	0.946	0.777	1.151	0.580	NR	NR	NR	NR
	SFC	Fluticasone propionate	0.768	0.636	0.927	0.006	NR	NR	NR	NR
	Salmeterol	Placebo	0.857	0.710	1.035	0.110	NR	NR	NR	NR
	Fluticasone propionate	Placebo	1.056	0.883	1.264	0.550	NR	NR	NR	NR
UPLIFT	Tiotropium	Placebo	0.890	0.790	1.020	0.086	0.840	0.730	0.970	0.016
POET-COPD	Tiotropium	Salmeterol	0.810	0.580	1.130	0.210	0.850	0.610	1.190	0.350
INSPIRE	SFC	Tiotropium	NR	NR	NR	NR	0.480	0.270	0.850	0.012

ISSN: 1471-2466