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Table 1 Population characteristics

From: Hypertonic saline (HS) for acute bronchiolitis: Systematic review and meta-analysis

Study Age—mean (SD) Gender Disease severity Length of hospital stay mean (SD) (days) Final CSS score
Al-Ansari 2010 et al. [68] Intervention (3 % HS): 3.84 (2.84) Intervention (3 % HS): F19 M39 Moderate to severe Intervention (3 % HS): 1.4 (1.41) NR
Intervention (5 % HS): 4.02 (2.56) Intervention (5 % HS): F26 M31   Intervention (5 % HS): 1.56 (1.38)
Control: 3.30 (2.43) Control: F26 M31   Control: 1.88 (1.76)
Espelt et al. 2012 [25] NR Intervention: F24 M26 Moderate Intervention: 5.8 (2.7) NR
Control: F26 M24   Control: 5.47 (2.1)
Everard et al. 2014 [73] Intervention: 3.3 (2.6) Intervention: F69 M73 Severe Intervention: 4.19 (3.20) NR
Control: 3.4 (2.8) Control: F64 M85   Control: 4.22 (3.52)
Giudice et al. 2012 [62] Intervention: 4.8 (2.3) Intervention: F18 M34 Severe Intervention: 4.9 (1.3) Intervention: 6.5 (1.6)
Control: 4.2 (1.6) Control:F19 M35   Control: 5.6 (1.6) Control: 7.7 (1.6)
Kuzik et al. 2007 [20] Intervention: 4.4 (3.7) Intervention: F20 M27 Moderate Intervention: 2.6 (1.9) NR
Control: 4.6 (4.7) Control: F19 M30   Control: 3.5 (2.9)
Luo et al. 2010 [63] Intervention: 6.0 (4.3) NR Mild to Intervention: 6 (1.2) Intervention: 1.5 (0.5)
Control: 5.6 (4.5)   moderate Control: 7.4 (1.5) Control: 2.9 (0.7)
Luo et al. 2011 [64] Intervention: 5.9 (4.1) NR Moderate to severe Intervention: 4.8 (1.2) Intervention: 1.7 (0.6)
Control: 5.8 (4.3)    Control: 6.4 (1.4) Control: 3.1 (0.7)
Maheshkumar et al. 2013 [67] NR NR Mild to moderate Intervention: 2.25 (0.89) NR
    Control: 2.88 (1.76)
Mandelberg et al. 2003 [18] Intervention: 3 (1.2) Intervention: F12 M15 Moderate Intervention: 3 (1.2) NR
Control: 2.6 (1.9) Control: F9 M15   Control: 4 (1.9)
Nemsadze et al. 2013 [69] NR NR Mild to moderate Intervention: 4.4 (1.1) NR
    Control: 4.9 (1.2)
Ojha et al. 2014 [72] Intervention: 8.61 (5.74) NR NR Intervention: 1.87 (0.96) NR
Control: 8.51 (4.24)    Control: 1.82 (1.18)
Ozdogan et al. 2014 [27] Overall: 7.1 (5.48) NR Mild to moderate NR NR
Pandit et al. 2013 [66] NR NR Moderate to severe Intervention: 3.92 (1.72) NR
    Control: 4.08 (1.90)
Sharma et al. 2013 [65] Intervention: 4.93 (4.31) Intervention: F28 M97 Moderate Intervention: 2.64 (0.88) NR
Control: 4.18 (4.24) Control: F31 M92   Control: 2.66 (0.93)
Silver et al. 2014 [71] Intervention: 3.86 (3.01) Intervention (3%HS): F31 M62 NR Intervention: 2.49 (1.64) NR
Control: 4.39 (2.95) Control: F37 M60   Control: 2.47 (1.76)
Sosa-Bustamante et al. 2014 [26] NR NR Moderate to severe NR NR
Tal et al. 2006 [19] Intervention: 2.8 (1.2) Intervention: F11 M10 Moderate Intervention: 2.6 (1.4) Intervention: 5.35 (1.3)
Control:2.3 (0.7) Control: F7 M13   Control: 3.5 (1.7) Control: 6.45 (1)
Teunissen et al. 2014 [70] Intervention (3 % HS): 3.6 (5.2) Intervention (3 % HS): F40 M44 Mild to moderate Intervention (3 % HS): 3.43 (2.24) Intervention (3 % HS): 3.87 (3.15)
Intervention (6 % HS): 3.4 (3.8) Intervention (6 % HS): F35 M48   Intervention (6 % HS): 3.74 (2.99) Intervention (6 % HS): 5.16 (4.20)
Control: 3.6 (5.0) Control: F31 M49   Control: 2.82 (2.25) Control: 4.61(5.38)
  1. F Female, M male, NR Not reported, HS Hypertonic saline