Table 1 Population characteristics
From: Hypertonic saline (HS) for acute bronchiolitis: Systematic review and meta-analysis
Study | Age—mean (SD) | Gender | Disease severity | Length of hospital stay mean (SD) (days) | Final CSS score |
|---|---|---|---|---|---|
Al-Ansari 2010 et al. [68] | Intervention (3 % HS): 3.84 (2.84) | Intervention (3 % HS): F19 M39 | Moderate to severe | Intervention (3 % HS): 1.4 (1.41) | NR |
Intervention (5 % HS): 4.02 (2.56) | Intervention (5 % HS): F26 M31 | Intervention (5 % HS): 1.56 (1.38) | |||
Control: 3.30 (2.43) | Control: F26 M31 | Control: 1.88 (1.76) | |||
Espelt et al. 2012 [25] | NR | Intervention: F24 M26 | Moderate | Intervention: 5.8 (2.7) | NR |
Control: F26 M24 | Control: 5.47 (2.1) | ||||
Everard et al. 2014 [73] | Intervention: 3.3 (2.6) | Intervention: F69 M73 | Severe | Intervention: 4.19 (3.20) | NR |
Control: 3.4 (2.8) | Control: F64 M85 | Control: 4.22 (3.52) | |||
Giudice et al. 2012 [62] | Intervention: 4.8 (2.3) | Intervention: F18 M34 | Severe | Intervention: 4.9 (1.3) | Intervention: 6.5 (1.6) |
Control: 4.2 (1.6) | Control:F19 M35 | Control: 5.6 (1.6) | Control: 7.7 (1.6) | ||
Kuzik et al. 2007 [20] | Intervention: 4.4 (3.7) | Intervention: F20 M27 | Moderate | Intervention: 2.6 (1.9) | NR |
Control: 4.6 (4.7) | Control: F19 M30 | Control: 3.5 (2.9) | |||
Luo et al. 2010 [63] | Intervention: 6.0 (4.3) | NR | Mild to | Intervention: 6 (1.2) | Intervention: 1.5 (0.5) |
Control: 5.6 (4.5) | moderate | Control: 7.4 (1.5) | Control: 2.9 (0.7) | ||
Luo et al. 2011 [64] | Intervention: 5.9 (4.1) | NR | Moderate to severe | Intervention: 4.8 (1.2) | Intervention: 1.7 (0.6) |
Control: 5.8 (4.3) | Control: 6.4 (1.4) | Control: 3.1 (0.7) | |||
Maheshkumar et al. 2013 [67] | NR | NR | Mild to moderate | Intervention: 2.25 (0.89) | NR |
Control: 2.88 (1.76) | |||||
Mandelberg et al. 2003 [18] | Intervention: 3 (1.2) | Intervention: F12 M15 | Moderate | Intervention: 3 (1.2) | NR |
Control: 2.6 (1.9) | Control: F9 M15 | Control: 4 (1.9) | |||
Nemsadze et al. 2013 [69] | NR | NR | Mild to moderate | Intervention: 4.4 (1.1) | NR |
Control: 4.9 (1.2) | |||||
Ojha et al. 2014 [72] | Intervention: 8.61 (5.74) | NR | NR | Intervention: 1.87 (0.96) | NR |
Control: 8.51 (4.24) | Control: 1.82 (1.18) | ||||
Ozdogan et al. 2014 [27] | Overall: 7.1 (5.48) | NR | Mild to moderate | NR | NR |
Pandit et al. 2013 [66] | NR | NR | Moderate to severe | Intervention: 3.92 (1.72) | NR |
Control: 4.08 (1.90) | |||||
Sharma et al. 2013 [65] | Intervention: 4.93 (4.31) | Intervention: F28 M97 | Moderate | Intervention: 2.64 (0.88) | NR |
Control: 4.18 (4.24) | Control: F31 M92 | Control: 2.66 (0.93) | |||
Silver et al. 2014 [71] | Intervention: 3.86 (3.01) | Intervention (3%HS): F31 M62 | NR | Intervention: 2.49 (1.64) | NR |
Control: 4.39 (2.95) | Control: F37 M60 | Control: 2.47 (1.76) | |||
Sosa-Bustamante et al. 2014 [26] | NR | NR | Moderate to severe | NR | NR |
Tal et al. 2006 [19] | Intervention: 2.8 (1.2) | Intervention: F11 M10 | Moderate | Intervention: 2.6 (1.4) | Intervention: 5.35 (1.3) |
Control:2.3 (0.7) | Control: F7 M13 | Control: 3.5 (1.7) | Control: 6.45 (1) | ||
Teunissen et al. 2014 [70] | Intervention (3 % HS): 3.6 (5.2) | Intervention (3 % HS): F40 M44 | Mild to moderate | Intervention (3 % HS): 3.43 (2.24) | Intervention (3 % HS): 3.87 (3.15) |
Intervention (6 % HS): 3.4 (3.8) | Intervention (6 % HS): F35 M48 | Intervention (6 % HS): 3.74 (2.99) | Intervention (6 % HS): 5.16 (4.20) | ||
Control: 3.6 (5.0) | Control: F31 M49 | Control: 2.82 (2.25) | Control: 4.61(5.38) |