Fig. 4

IPF genomic model predicts prognosis in two independent validation cohorts. The prognosis prediction specificity was assessed in University of Chicago validation cohort (UCV, panel a) and University of Pittsburgh validation cohort (UPV, panel b). IPF patients with predicted low (dotted line) and high risk (dashed line) stratified by prognostic index (PI) derived from each patient in UCV and UPV cohorts based on the genomic model. The red line denotes 50 % probability of survival. PI significantly predicted survival in univariate competing-event Cox regression in the UCV (SHR 2.0; 95 % CI 1.2-3.4; p = 0.005) and UPV (SHR 1.8; 95 % CI 1.1-2.7; p = 0.01) cohorts. This association remained in the UCV (SHR 1.7; 95 % CI 1.04-2.93; p = 0.035) and UPV (SHR 1.9; 95 % CI 1.2-3.0; p = 0.005) cohorts after adjusting for baseline CPI in multivariate Cox regression