Table 3 Independent significant risk factors of death^a (N = 5,548) – Reduced model

Age

 ≤50 years

1

 51-70 years

1.18

[0.89; 1.59]

0.267

 >70 years

1.51

[1.11; 2.08]

0.011

Sex

 Men

4,179

1

1

 Women

1,369

0.69

[0.52; 0.9]

0.007

0.86

[0.71; 1.04]

0.129

Weight loss within the 3 preceding months

 No

2,545

1

1

 Yes

3,003

1.4

[1.09; 1.81]

0.01

1.54

[1.3; 1.82]

<0.001

Smoking status

 Never-smoker

1

 Former-smoker

1.38

[1.05; 1.83]

0.024

 Active-smoker

1.36

[1.03; 1.81]

0.031

Performance status at diagnosis

 0- Fully active

1,576

1

1

 1- Restricted in heavy physical work

2,362

2

[1.27; 3.28]

0.004

1.82

[1.43; 2.34]

<0.001

 2- Up and about more than half the day

1,002

6.5

[4.14; 10.63]

<0.001

5.07

[3.92; 6.6]

<0.001

 3- In bed or sitting in a chair more than half the day

496

20.2

[12.84; 33.15]

<0.001

17.27

[12.93; 23.25]

<0.001

 4- In bed or in a chair all the time

112

71.9

[41; 130.28]

<0.001

44.23

[26.29; 77.66]

<0.001

Stage (7 edition)

 Stage ≤ IIB

901

1

1

 Stage IIIA

759

0.75

[0.38; 1.46]

0.397

1.17

[0.79; 1.74]

0.436

 Stage IIIB

570

2.17

[1.24; 3.88]

0.008

2.44

[1.68; 3.56]

<0.001

 Stage IV

3,318

2.36

[1.49; 3.92]

<0.001

3.66

[2.72; 5.02]

<0.001

Histology

 Adenocarcinoma

2,521

1

1

 Small-cell carcinoma

758

1.39

[1.03; 1.87]

0.032

0.73

[0.58; 0.92]

0.008

 Squamous-cell carcinoma

1,440

0.89

[0.66; 1.2]

0.454

0.91

[0.75; 1.11]

0.348

 Large-cell carcinoma

586

1.72

[1.23; 2.38]

0.001

1.33

[1.04; 1.68]

0.022

 Adenocarcinoma in situ

48

2.05

[0.45; 6.43]

0.275

1.59

[0.62; 3.64]

0.298

 Carcinoid tumour

78

1.01

[0.36; 2.45]

0.983

1.01

[0.5; 1.95]

0.983

 Other

117

1.44

[0.58; 3.13]

0.396

1.17

[0.63; 2.06]

0.601