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Table 3 Description of Cluster at 12 months. Values shown number of subjects, and percentage of total subjects [n (%)] unless otherwise stated

From: Phenotyping of difficult asthma using longitudinal physiological and biomarker measurements reveals significant differences in stability between clusters

Variable Phenotype A (n = 25) Phenotype B (n = 16) Phenotype C (n = 33) Phenotype D (n = 51) p-value
FEV1 < 80 % 22 (88.0) 8 (50.0) 29 (87.9) 19 (37.3) <0.01
Beclamethasone or equivalent dose >1600mcg 4 (16.0) 2 (12.5) 5 (15.2) 8 (15.7) 0.99
AOO < 20 year 7 (28.0) 7 (43.8) 30 (90.9) 14 (27.5) <0.01
ACQ ≤ 1 6 (24.0) 5 (31.2) 13 (39.4) 21 (41.2) 0.48
Female 9 (36.0) 9 (56.2) 11 (33.3) 30 (58.8) 0.07
Severe asthmatic 21 (84.0) 9 (56.2) 24 (72.7) 23 (45.1) <0.01
Atopic 19 (76.0) 13 (81.2) 27 (81.8) 41 (80.4) 0.95
Non-Smoker 19 (76.0) 13 (81.2) 22 (66.7) 23 (45.1) 0.01
Age [mean (SD)] 49.0 (11.6) 44.4 (8.8) 52.4 (12.4) 47.2 (12.7) 0.12
BMI [mean (SD)] 26.8 (4.4) 40.1 (4.6) 26.5 (4.1) 25.7 (3.7) <0.01
Sputum Neutrophils (%) [mean (SD)] 45.9 (29.1) 50.0 (25.2) 44.5 (29.2) 43.8 (29.5) 0.90
Sputum Eosinophils (%) [mean (SD)] 6.2 (6.2) 8.5 (6.3) 8.8 (9.9) 31.5 (12.7) <0.01
FENO (ppb) [mean (SD)] 33.8 (35.1) 23.1 (22.2) 26.6 (23.3) 24.1 (21.5) 0.42
  1. Abbreviations: FEV 1 Forced Expiratory Volume at 1 s, ICS inhaled corticosteroid, AOO age of onset of asthma, ACQ Asthma Control Questionnaire score, BMI body mass index, F E NO fractional of exhaled nitric oxide in parts per billion (ppb). Chi-square test was used for categorical variables, and one-way ANOVA was performed for continuous variables