Table 3 Description of Cluster at 12 months. Values shown number of subjects, and percentage of total subjects [n (%)] unless otherwise stated
Variable | Phenotype A (n = 25) | Phenotype B (n = 16) | Phenotype C (n = 33) | Phenotype D (n = 51) | p-value |
|---|---|---|---|---|---|
FEV1 < 80 % | 22 (88.0) | 8 (50.0) | 29 (87.9) | 19 (37.3) | <0.01 |
Beclamethasone or equivalent dose >1600mcg | 4 (16.0) | 2 (12.5) | 5 (15.2) | 8 (15.7) | 0.99 |
AOO < 20 year | 7 (28.0) | 7 (43.8) | 30 (90.9) | 14 (27.5) | <0.01 |
ACQ ≤ 1 | 6 (24.0) | 5 (31.2) | 13 (39.4) | 21 (41.2) | 0.48 |
Female | 9 (36.0) | 9 (56.2) | 11 (33.3) | 30 (58.8) | 0.07 |
Severe asthmatic | 21 (84.0) | 9 (56.2) | 24 (72.7) | 23 (45.1) | <0.01 |
Atopic | 19 (76.0) | 13 (81.2) | 27 (81.8) | 41 (80.4) | 0.95 |
Non-Smoker | 19 (76.0) | 13 (81.2) | 22 (66.7) | 23 (45.1) | 0.01 |
Age [mean (SD)] | 49.0 (11.6) | 44.4 (8.8) | 52.4 (12.4) | 47.2 (12.7) | 0.12 |
BMI [mean (SD)] | 26.8 (4.4) | 40.1 (4.6) | 26.5 (4.1) | 25.7 (3.7) | <0.01 |
Sputum Neutrophils (%) [mean (SD)] | 45.9 (29.1) | 50.0 (25.2) | 44.5 (29.2) | 43.8 (29.5) | 0.90 |
Sputum Eosinophils (%) [mean (SD)] | 6.2 (6.2) | 8.5 (6.3) | 8.8 (9.9) | 31.5 (12.7) | <0.01 |
FENO (ppb) [mean (SD)] | 33.8 (35.1) | 23.1 (22.2) | 26.6 (23.3) | 24.1 (21.5) | 0.42 |