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Table 5 Comparison of Mean Absolute Change in Sputum eosinophils (%) and FEV1 (%) between subjects who changed cluster as opposed to those who did not change cluster

From: Phenotyping of difficult asthma using longitudinal physiological and biomarker measurements reveals significant differences in stability between clusters

Flux Period Patients with no change in cluster Patients with change in cluster p-value
Baseline to 3 months N 85 40  
Absolute change in FEV1(%) Mean (SD) 6.2 (5.6) 12.1 (15.1) 0.02
Absolute change in Eos (%) Mean (SD) 5.9 (6.2) 16.7 (15.1) <0.01
Baseline to 6 months N 97 28  
Absolute change in FEV1(%) Mean (SD) 5.6 (6.0) 16.1 (17.0) <0.01
Absolute change in Eos(%) Mean (SD) 6.1 (7.3) 22.1 (15.9) <0.01
Baseline to 9 months N 98 27  
Absolute change in FEV1(%) Mean (SD) 6.6 (5.9) 16.7 (16.0) <0.01
Absolute change in Eos Mean (SD) 7.9 (8.3) 19.9 (14.3) <0.01
Baseline to 12 months N 95 30  
Absolute change in FEV1(%) Mean (SD) 8.3 (7.8) 15.1 (15.1) 0.03
Absolute change in Eos Mean (SD) 7.8 (8.7) 16.3 (14.2) <0.01