Table 1 Overall dropout rate and main reasons for treatment discontinuation in RCT
Author [ref] | N | duration (months) | Mean ± SD age, years | M/F Ratio | Drop-out rate (%) | Patient decision (%) | Lack of efficacy (%) | Adverse events (%) | Other Causes (%) |
|---|---|---|---|---|---|---|---|---|---|
Busse et al. 2001 [16] | 268 | 7 | 39.3 | 0.63 | 7.1 | 4.1 | 0.37 | 0.74 | 1.49 |
Soler et al. 2011 [23] | 274 | 7 | 40.0 | 1.06 | 6.9 | 1.09 | 1.09 | NR | NR |
Holgate et al. 2004 [21] | 126 | 8 | 41.1 | 0.55 | 8.7 | 8.7 | NR | NR | NR |
Ayres et al. 2004 [19] | 206 | 12 | 37.5 | 0.39 | 7.3 | NR | NR | 7.3 | NR |
Vignola et al. 2004 [24] | 209 | 7 | 38.3 ± 14.7 | 0.92 | 8.1 | 8.1 | NR | NR | NR |
Humbert et al 2005 [22] | 209 | 7 | 43.4 ± 13.3 | 0.48 | 12.2 | NR | NR | 4.5 | NR |
Hanania et al. 2011 [20] | 427 | 12 | 43.7 ± 14.3 | 0.63 | 19.4 | 11.00 | NR | 3.74 | 4.68 |