Fig. 2From: Acute exacerbation of IPF has systemic consequences with multiple organ injury, with SRA+ and TNF-α+ cells in the systemic circulation playing central roles in multiple organ injuryType 2 acute inflammatory lung injury (a, b) and cardiac injury (c, d). a Alveolar epithelial cells absent from alveoli (arrow) and cytokeratin positive cell debris in air spaces. b Accumulation of platelets mostly in the capillaries of the alveolar septa. c Contraction band necrosis of a variety of durations. d Accumulation of neutrophils mostly in capillaries. Scale bar: 30 μm (a-d). Immunohistochemistry for AE1/AE3 (a) and CD42b (b). Phosphotungstic acid hematoxylin (c)Back to article page