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Table 1 Histopathologic and cytologic findings

From: Acute exacerbation of IPF has systemic consequences with multiple organ injury, with SRA+ and TNF-α+ cells in the systemic circulation playing central roles in multiple organ injury

 

Age

Sex

AE-D

Lung

Heart

Liver

Kid.

Sto.

Large SRA+ cells

TNF-α+ cells

Before AE

At Death

After AE

At Death

1

83

M

4

DAD(E)

<1

ND

5

ND

1

2

82

M

26

DAD(E,P)

many

+

+

1

66

0

4

3

83

M

35

DAD(E,P)

2

ND

12

ND

2

4

63

M

24

DAD(E,P)

many

+

+

2

609

1

5

5

58

F

7

DAD(E,P)

many

+

+

+

0

2

0

3

6

45

M

30

DAD(E,P)

7

+

+

+

1

44

4

2

7

59

F

27

DAD(E,P)

many

+

+

4

1015

1

7

8

73

M

20

DAD(E,P)

many

2

84

2

3

9

64

M

60

DAD(E,P)

47

+

+

+

1

413

3

2

10

68

M

16

DAD(E,P)

38

+

+

1

91

0

4

11

61

M

30

DAD(E,P)

20

+

+

1

189

2

5

12

63

F

50

DAD(E,P)

8

5

546

5

8

13

74

M

75

DAD(E,P)

31

+

3

72

2

1

14

87

M

7

DAD(E)

many

+

+

5

4

1

2

  1. AE-D represents the duration from the diagnosis of acute exacerbation to death (days). Abbreviations: AE acute exacerbation, Kid Kidney, Sto Stomach, SRA Scavenger receptor A, TNF Tumor necrosis factor, M Male, F Female, DAD Diffuse alveolar damage, E Exudative phase, P Proliferative phase, ND No data