Table 6 Trends in pre-bronchodilator (PreBD) spirometric parameters during follow up

FVC (L)

2.5 (2.1–3.2)

2.7 (2.2–3.3)

2.4 (1.9–3.0)

<0.01

<0.01

<0.00

FVC (% pred)

82.0 (65.0–94.0)

88.0 (72.0–101.0)

77.1 (67.1–88.0)

<0.01

<0.01

<0.00

FEV₁ (L)

1.5 (1.2–2.0)

1.8 (1.3–2.2)

1.5 (1.1–2.0)

<0.01

<0.01

<0.00

FEV₁ (%pred)

59.5 (45–75.8)

66.5 (54.0–82.3)

63.0 (49.4–73.4)

<0.01

<0.01

<0.00

FEV₁/FVC

0.6 (0.5–0.7)

0.7 (0.5–0.7)

0.7 (0.6–0.7)

0.04

0.69

0.03

FEV₁/FVC (%pred)

75.0 (63.8–89.3)

79.0 (64.8–88.0)

80.4 (70.1–88.8)

0.02

0.16

<0.00

FEF_25–75% (L/s)

0.5 (0.8–1.3)

0.9 (0.5–1.7)

0.8 (0.6–1.4)

<0.01

0.04

<0.01

FEF_25–75% (%pred)

27.0 (17.0–48.5)

33.0 (21.0–52.0)

34.5 (24.1–51.0)

<0.01

0.19

<0.00